Figure 4.

Results from global sensitivity analysis performed for kinetic parameters representing DAT conformational dynamics. Yellow dots represent the default parameters used in the present study, and blue dots show the results obtained by using as input random combinations of the parameters (k₁₂, k₂₃, k₃₄, k₄₁ and k₁₄) and their ratios. Results for k₃₄, which are very similar to those for k₂₃, are not shown. The red curves indicate the mean values and the standard error for successive bins of width 0.5. The Spearman correlation coefficients are –0.71, 0.01, –0.01, –0.44, 0.44, 0.63, and –0.48, in the six respective panels.