Table 2.
Clinical symptoms observed in VLP-immune ferrets challenged with H7N9 virus.
| Vaccine groupa | Clinical symptoms of H7N9 challenged ferrets | ||
|---|---|---|---|
|
| |||
| Mean temp increase over baseline (3C)b | Mean % weight lossc | Mean peak viral titerd | |
| VLP | 2.0 | 7.4 | 5.0 ± 0.18 |
| VLP + ISCOMATRIX | 1.3 | 3.5 | 4.2 ± 0.04 |
| PBS | 2.3 | 12.7 | 6.5 ± 0.11 |
a
Ferrets were vaccinated i.m. two times with the 15 μg of H7N9 VLP.
b
Temperature increases over ferret baseline of 38.5 ± 0.2 °C, all maximum temperatures from day 2 p.c.
c
Mean maximum weight loss percentage values shown (day 7 or 8 post-challenge) for 6 ferrets per group.
d
Virus detected in nasal wash samples, mean peak titer shown as log10 pfu/ml including standard deviation. All peak titers from day 2 p.c.