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Flowchart of participation in the Doetinchem Cohort Study. Note: in the second round a random sample (n = 7768) of the 12,404 adults who initially participated was reinvited because of budgetary reasons. In subsequent rounds, adults dropped out due to, for instance, emigration, death, and active withdrawal. Common reasons for active withdrawal were no time or interest to participate and participation in other medical investigations.
