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. 2017 Jun 27;32(2):332–342. doi: 10.1038/leu.2017.177

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Structural rearrangements in IgHV^unmut and IgHV^mut CLL. Circos plot depicting the frequency and locations of CNAs and translocations detected in 46 CLL genomes. The two outermost tracks represent CNAs: CN loss (red) and CN gain (green). Copy number data is displayed as the percentage of each IgHV subgroup affected. The centre plot shows translocations identified in the cohort. Red links indicate tier 1 events (gene:gene), green links indicate tier 2 events (gene:intergenic) and grey indicate tier 3 (intergenic:intergenic). The widths of the bands are indicative of the number of patients affected by the translocation.