Table 2.
Median and inter-quartile ranges (IQR) of striatal and thalamic tissue content and neurometabolite concentrations in the study groups of WELDOX II.
| Total | Welders | Former welders | Controls | Parkinson patients | Haemochromatosis patients | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Median | IQR | Median | IQR | Median | IQR | Median | IQR | Median | IQR | Median | IQR | |
| Striatum | ||||||||||||
| Grey matter [%] | 32.5 | 30.3; 35.1 | 32.1 | 29.5; 35.5 | 32.6 | 31.0; 35.3 | 33.6 | 31.0; 36.6 | 31.6 | 29.9; 33.6 | 31.7 | 29.7; 33.7 |
| White matter [%] | 55.0 | 52.1; 57.7 | 55.4 | 52.4; 57.5 | 54.7 | 51.8; 56 | 55.2 | 52.7; 57.3 | 54.3 | 50.8; 58.4 | 54.4 | 53.0; 58.0 |
| Cerebrospinal fluid [%] | 12.0 | 9.0; 15.1 | 11.2 | 9.0; 15.7 | 12.4 | 8.7; 14.5 | 11.1 | 7.9; 13.2 | 13.2 | 9.9; 16.7 | 13.1 | 10.1; 15.7 |
| γ-aminobutyric acid (GABA) [mM] | 2.0 | 1.8; 2.2 | 2.0 | 1.8; 2.2 | 1.9 | 1.7; 2.1 | 1.9 | 1.8; 2.0 | 2.0 | 1.8; 2.2 | 2.1 | 1.8; 2.5 |
| Glutamate [mM] | 6.7 | 5.9; 7.3 | 6.8 | 6.2; 7.3 | 6.6 | 5.9; 6.9 | 6.8 | 5.8; 7.3 | 6.7 | 5.9; 7.5 | 6.1 | 5.4; 6.3 |
| Glutamate and glutamine [mM] | 10.3 | 9.1; 11.3 | 10.2 | 9.1; 11.4 | 10.0 | 9.1; 11.0 | 10.5 | 9.3; 11.3 | 10.5 | 9.1; 11.7 | 9.9 | 9.0; 10.6 |
| Total creatine [mM] | 7.1 | 6.7; 7.6 | 7.1 | 6.7; 7.5 | 6.9 | 6.7; 7.3 | 7.4 | 6.9; 7.8 | 7.2 | 6.5; 7.6 | 6.9 | 6.3; 7.2 |
| Total choline [mM] | 2.2 | 2.0; 2.4 | 2.2 | 1.9; 2.4 | 2.0 | 1.9; 2.3 | 2.3 | 2.0; 2.5 | 2.2 | 2.1; 2.6 | 2.1 | 2.0; 2.4 |
| N-acetyl aspartate (NAA) [mM] | 6.4 | 5.9; 6.8 | 6.5 | 6.1; 6.8 | 6.1 | 5.5; 6.9 | 6.6 | 6.1; 6.9 | 6.4 | 5.8; 6.9 | 6.4 | 5.5; 6.5 |
| Total NAA [mM] | 6.6 | 6.2; 7.1 | 6.7 | 6.2; 7.2 | 6.4 | 5.9; 7.1 | 6.6 | 6.3; 6.9 | 6.6 | 6.1; 7.1 | 6.5 | 6.1; 6.8 |
| Myo-inositol [mM] | 4.4 | 3.9; 4.8 | 4.4 | 4.0; 4.7 | 4.1 | 3.8; 5.0 | 4.3 | 3.9; 4.7 | 4.4 | 3.9; 5.0 | 4.4 | 4.0; 4.6 |
| Thalamus | ||||||||||||
| Grey matter [%] | 20.9 | 19.5; 22.3 | 21.0 | 19.2; 22.1 | 21.6 | 19.8; 23.2 | 20.7 | 19.2; 22.3 | 20.9 | 19.7; 21.8 | 21.3 | 20.0; 23.8 |
| White matter [%] | 70.7 | 67.4; 73.5 | 70.1 | 66.9; 73.5 | 69.7 | 66.6; 70.9 | 73.2 | 69.8; 75.1 | 70.7 | 67.1; 73.0 | 69.4 | 67.9; 71.2 |
| Cerebrospinal fluid [%] | 8.3 | 5.7; 10.7 | 8.7 | 6.4; 10.8 | 10.1 | 7.5; 11.0 | 5.7 | 4.6; 8.5 | 8.6 | 6.4; 10.9 | 9.3 | 6.8; 10.8 |
| GABA [mM] | 2.0 | 1.8; 2.3 | 2.0 | 1.7; 2.2 | 2.0 | 1.8; 2.3 | 1.9 | 1.7; 2.4 | 2.1 | 1.9; 2.4 | 1.9 | 1.6; 2.1 |
| Glutamate [mM] | 5.5 | 5.0; 6.1 | 5.9 | 5.4; 6.3 | 5.6 | 5.0; 6.2 | 5.3 | 5.0; 5.9 | 5.5 | 5.0; 5.9 | 5.3 | 4.6; 6.0 |
| Glutamate and glutamine [mM] | 7.8 | 6.8; 8.9 | 8.0 | 7.3; 9.1 | 8.4 | 6.3; 9.2 | 7.0 | 6.4; 8.3 | 7.6 | 6.8; 8.5 | 7.5 | 6.6; 9.6 |
| Total creatine [mM] | 6.4 | 6.1; 6.8 | 6.6 | 6.2; 6.8 | 6.4 | 6.1; 6.7 | 6.3 | 6.1; 6.7 | 6.3 | 6.0; 6.8 | 6.1 | 6.1; 6.7 |
| Total choline [mM] | 2.1 | 2.0; 2.2 | 2.1 | 2.0; 2.3 | 2.0 | 1.9; 2.3 | 2.0 | 1.9; 2.1 | 2.1 | 2.0; 2.2 | 2.1 | 1.9; 2.2 |
| NAA [mM] | 6.8 | 6.4; 7.2 | 7.0 | 6.5; 7.3 | 6.8 | 6.4; 7.1 | 6.7 | 6.2; 7.2 | 6.9 | 6.3; 7.3 | 6.8 | 6.6; 7.3 |
| Total NAA [mM] | 7.5 | 7.0; 8.0 | 7.9 | 7.3; 8.3 | 7.5 | 6.9; 7.9 | 7.4 | 7.0; 7.8 | 7.4 | 6.8; 7.9 | 7.5 | 7.1; 7.8 |
| Myo-inositol [mM] | 4.7 | 4.2; 5.1 | 4.7 | 4.1; 5.1 | 4.6 | 4.1; 5.1 | 4.6 | 4.2; 4.8 | 4.8 | 4.2; 5.4 | 4.5 | 4.1; 5.0 |
Neurometabolites: arithmetic mean of both hemispheres.