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. 2018 Feb 6;5(1):ENEURO.0305-17.2018. doi: 10.1523/ENEURO.0305-17.2018

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Copyright © 2018 Elliott et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 3. — Effect of serotonin on type I and type II pyramidal cells of L5. A₁, Administration of serotonin (10 μm) to an electrophysiologically identified type I pyramidal cell of L5 elicits an inward current that recovers after removal of serotonin from the bath. A₂, Summary plot illustrating the mean current (± SEM) elicited by serotonin on 38 type I cells of L5. Vh = –60 mV. B₁, Administration of serotonin (10 μm) to an electrophysiologically identified type II cell of L5 elicits an outward current that recovers on removal of serotonin from the bath. B₂, Summary plot illustrating the mean current (± SEM) elicited by serotonin on 59 type II cells tested. Vh = –60 mV. Notice that the initial outward current is followed a net inward current as previously reported for many of these cells (Araneda and Andrade, 1991). B₂ inset, Bar graph illustrating the peak initial current induced by serotonin. *, p < 0.001. C, 3D plot graphing the time constant of I_h, the amplitude of I_sAHP, and the amplitude of the initial current induced by serotonin in the cell sampled in the current work. D, Amplitudes distribution for the initial serotonin-induced current in type I and type II cells.