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. 2018 Feb 6;5(1):ENEURO.0305-17.2018. doi: 10.1523/ENEURO.0305-17.2018

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Copyright © 2018 Elliott et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — Pharmacology of serotonin responses in type I and type II L5 pyramidal cells of rat mPFC. A₁, Top, two consecutive applications of serotonin (10 μm) to a type I pyramidal cell results in comparable inward currents indicating minimal desensitization of the response. Bottom, administration of the selective 5-HT_2A receptor antagonist MDL100 907 (300 nm) between serotonin application inhibits the effect of a second serotonin application. A₂, Summary plot illustrating the effect of MDL100907 on the inward current elicit by serotonin on type I pyramidal cells. B₁, Top, two consecutive applications of serotonin (10 μm) to a type II pyramidal cell elicit comparable outward currents. Bottom, administration of the selective 5-HT_1A antagonist WAY100135 (3 μm) between serotonin application blocks the effect of a second application of serotonin. B₂, Summary plot illustrating the effect of WAY100135 on the outward current elicited by serotonin in type II pyramidal cells.