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. 2018 Jan 16;12(12):1092–1100. doi: 10.1080/15592294.2017.1403692

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 3. — Effect size of association between urine cotinine levels and DNA methylation in monocytes. A volcano plot depicts the significance [-log10(P value), y-axis] vs. the effect size (beta, x-axis) from the associations between DNA methylation (M-value) and log urine cotinine levels (ng/ml) for each of the 484,817 CpG sites investigated (significant results not previously identified shown as golden circles; top seven most significant genomic loci shown as green circles; red line indicates genome-wide significance, FDR < 0.01).