. 2017 Dec 15;9(5):6416–6432. doi: 10.18632/oncotarget.23740

Table 1B. Non MYCN-amplified group: Prominent nucleolar formation and prognostic factors by MYCN protein and MYC protein expression.

MYCN-P	MYC-P	PN		Age		Ploidy		INSS Stage		Grade
MYCN-P	MYC-P	(−)	(+)	< 18 months	≥18 months	Hyper-diploid	Diploid	Non-stage 4	Stage 4	U	PD
(+)	any	2	5	1	6	3	4	1	6	0	7
(−)/(+/−)	(−)/(+/−)	61	14	25	50	46	26	24	51	2	73
p-value		0.0064		0.4223		0.4171		0.4306		1.0000
any	(+)	6	33	12	27	23	13	13	26	2	37
(−)/(+/−)	(−)/(+/−)	61	14	25	50	46	26	24	51	2	73
p-value		< 0.0001		0.7815		1.0000		0.8853		0.6053
Either (+)		8	38	13	33	26	17	14	32	2	44
(−)/(+/−)	(−)/(+/−)	61	14	25	50	46	26	24	51	2	73
p-value		< 0.0001		0.5595		0.7135		0.8571		0.6344

MYCN-P = MYCN protein; MYC-P = MYC protein; PN = Prominent nucleolar formation; Age = Age at diagnosis; Ploidy = DNA ploidy pattern; INSS = International Neuroblastoma Staging System; Grade = Grade of neuroblastic differentiation; U = Undifferentiated; PD = Poorly differentiated.