Table 2B. EFS and OS by MYCN-P and MYC-P status, controlling for MYCN amplification.
| Cohort | Number | 4-year EFS ± SE (%) |
EFS p-value | 4-year OS ± SE (%) |
OS p-value | |
|---|---|---|---|---|---|---|
| MYCN amplified | ||||||
| MYCN-P | MYC-P | |||||
| (+) (−)/(+/−) |
(−)/(+/−) (−)/(+/−) |
101 (86%) 16 (14%) |
50.0 ± 6.7 76.9 ± 18.5 |
0.1111 | 55.6 ± 6.7 84.6 ± 16.6 |
0.0898 |
| MYCN amplified | ||||||
| MYCN−P (+) and/or MYC−P (+) Both proteins (−)/(+/−) |
104 (87%) 16 (13%) |
50.0 ± 6.6 76.9 ± 18.5 |
0.1139 | 56.3 ± 6.6 84.6 ± 16.6 |
0.0965 | |
| Non-MYCN amplified | ||||||
| MYCN-P | MYC-P | |||||
| (+) (−)/(+/−) (−)/(+/−) |
(−)/(+/−) (+) (−)/(+/−) |
7 (6%) 36 (31%) 75 (64%) |
34.3 ± 27.8 48.3 ± 20.1 64.1 ± 13.6 |
0.1176 | 34.3 ± 27.8 54.4 ± 18.4 79.4 ± 11.4 |
0.0750 |
| Non-MYCN amplified | ||||||
| MYCN−P (+) and/or MYC−P (+) Both proteins (−)/(+/−) |
46 (38%) 75 (62%) |
49.1 ± 17.5 64.1 ± 13.6 |
0.1192 | 51.2 ± 16.0 79.4 ± 11.4 |
0.1095 | |
EFS = Event-free survival; OS = Overall survival; SE = standard error; MYCN-P = MYCN protein; MYC-P = MYC protein