Fig. 5.

Increased immune cell infiltration and a reduced immunoregulatory environment in NOD intestinal tissue. Colonic lamina propria cells were analyzed by FACS for a CD45⁺ cells (n = 5–6), b CD90⁺ T cells (n = 5–7), c Foxp3⁺CD103⁺CD4⁺ regulatory T cells (n = 5–11), and d CD11b⁺F480⁺ macrophages (n = 3–6). Gene expression relative to HPRT was determined for IL10 (e) and IL22 (f) in the colon and ileum tissue