Table 3. Multivariable Negative Binomial Regression Models Assessing the Association Between Exposure to Antithrombotic Agents (Primary Exposure) and Hematuria-Related Complications.
| Variable | Association of Antithrombotic Medication Exposure, Stratified by Age at Prescription | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Patients 66-69 y | Patients 70-74 y | Patients 75-79 y | Patients 80-84 y | Patients ≥85 y | ||||||
| Unexposed | Exposed | Unexposed | Exposed | Unexposed | Exposed | Unexposed | Exposed | Unexposed | Exposed | |
| Sample size | 1 254 546 | 388 435 | 180 692 | 158 444 | 127 262 | 130 623 | 77 235 | 80 197 | 69 432 | 51 194 |
| Exposure time (person-years) | 9 166 367 | 563 189 | 2 966 576 | 605 332 | 2 008 765 | 607 366 | 1 082 624 | 473 134 | 640 373 | 351 500 |
| Any Hematuria-Related Complication | ||||||||||
| No. of events | 663 547 | 59 870 | 274 000 | 77 477 | 189 025 | 83 645 | 96 960 | 62 888 | 48 369 | 38 442 |
| Incidence density ratea | 72.39 | 106.31 | 92.36 | 127.99 | 94.1 | 137.72 | 89.56 | 132.92 | 75.53 | 109.37 |
| Adjusted rate ratio (95% CI)b | 1.18 (1.15-1.20) | 1.56 (1.53-1.60) | 1.78 (1.74-1.81) | 1.82 (1.77-1.86) | 1.65 (1.60-1.69) | |||||
| P Value | <.001 | <.001 | <.001 | <.001 | <.001 | |||||
| Emergency Department Visits | ||||||||||
| No. of events | 18 098 | 3159 | 8409 | 3929 | 6521 | 4643 | 4087 | 3729 | 2731 | 2862 |
| Incidence density ratea | 1.97 | 5.61 | 2.84 | 6.49 | 3.25 | 7.64 | 3.78 | 7.88 | 4.27 | 8.14 |
| Adjusted rate ratio (95% CI)b | 2.17 (2.07-2.28) | 2.75 (2.63-2.88) | 3.55 (3.40-3.70) | 3.97 (3.79-4.15) | 4.74 (4.51-4.99) | |||||
| P Value | <.001 | <.001 | <.001 | <.001 | <.001 | |||||
| Hospitalizations | ||||||||||
| No. of events | 45 542 | 5468 | 17 178 | 6636 | 12 179 | 7155 | 6937 | 5697 | 4105 | 3949 |
| Incidence density ratea | 4.97 | 9.71 | 5.79 | 10.96 | 6.06 | 11.78 | 6.41 | 12.04 | 6.41 | 11.24 |
| Adjusted rate ratio (95% CI)b | 1.51 (1.46-1.56) | 1.83 (1.78-1.89) | 2.09 (2.03-2.16) | 2.29 (2.22-2.37) | 2.35 (2.26-2.45) | |||||
| P Value | <.001 | <.001 | <.001 | <.001 | <.001 | |||||
| Urologic Procedures | ||||||||||
| No. of events | 599 896 | 51 238 | 248 400 | 66 909 | 170 316 | 71 844 | 85 932 | 53 455 | 41 533 | 31 630 |
| Incidence density ratea | 65.45 | 90.98 | 83.73 | 110.53 | 84.79 | 118.29 | 79.37 | 112.98 | 64.86 | 89.99 |
| Adjusted rate ratio (95% CI)b |
1.11 (1.08-1.13) | 1.48 (1.45-1.52) | 1.67 (1.64-1.71) | 1.69 (1.64-1.73) | 1.47 (1.42-1.51) | |||||
| P Value | <.001 | <.001 | <.001 | <.001 | <.001 | |||||
a
Incidence density rates are expressed as the number of events per 1000 person-years.
b
Models adjusted for association of participant sex, comorbidity, rurality, income quintile, and geographic region of residence. Among all these variables, a significant interaction was found between age and antithrombotic use (type 3 P < .001). Test for trend using Cochran-Armitage test for age group, P < .001. Rate ratios comparing antithrombotic exposed and unexposed periods, with stratification by patient age owing to a significant interaction between these 2 variables.