Figure 6.

Schematic of dual positive-negative selection chip. Beads in the first pinch are coated with multiple non-target proteins for negative selection, while beads in the second pinch are coated with the target of interest. The oligos are flowed through inlet 1, and only sequences with affinity for the target but not for any of the negative proteins will bind in the second pinch. These oligos are then eluted by the addition of DDT to inlet 2. Adapted from Wang et al⁸⁰ with permission from the American Chemical Society.