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. Author manuscript; available in PMC: 2019 Mar 15.
Published in final edited form as: Neuropharmacology. 2017 Dec 5;131:96–103. doi: 10.1016/j.neuropharm.2017.12.006

Figure 3.

Figure 3

Number of METH infusions after treatment with R-MOD and its analogues. R-MOD at a dose of 100 mg/kg decreased the number of infusions in the ShA 1 h group (A) and LgA group in the 1st hour (B). R-MOD decreased the total number of METH infusions in the LgA group over 6 h but not significantly (p = 0.058) (C). (D, F) JJC8-016 at a dose of 30 mg/kg decreased the number of infusions in the ShA 1 h group (D) and LgA group in the 1st hour (E) and in the 6 h session (F). (G-I) JJC8-088 did not affect METH intake in the ShA 1 h group (G) or in the LgA group in the 1st hour (H) or in the 6 h session (I). JJC8-089 at a dose of 30 mg/kg decreased the number of infusions in the ShA 1 h group and in the LgA group in the 6 h session. JJC8-091 at a dose of 56 mg/kg decreased the number of infusions in the ShA 1 h group and in the LgA group in the 1st hour. JJC8-091 at doses of 10, 30, and 56 mg/kg decreased the number of infusions in the LgA group in the 6 h session. +p < 0.05, ++p < 0.01, +++p < 0.001 main effect of group (ShA 1 h vs. LgA 1st h); #p < 0.05, main effect of dose; **p < 0.01, ***p < 0.001, different from vehicle.