Skip to main content
. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Transplantation. 2018 Mar;102(3):e90–e100. doi: 10.1097/TP.0000000000002044

Figure 1. Individual graft survival time and histological analysis of monkey cardiac allografts.

Figure 1

(A) sc28AT (blue) significantly prolonged allograft survival relative to no treatment (grey) (median survival time (MST), 34 vs. 6 days; P<0.05). There was no statistically significant difference in allograft survival comparing hu5C8-treated recipients (green, MST 133 days) with sc28AT+hu5C8-treated recipients (red, MST 141 days). Vertical hash marks represent animals that died or underwent euthanasia or elective explantation with functional allografts. (B) During the first 3 months after transplantation, ISHLT rejection scores of biopsy and functional (open boxes) or rejected (grey boxes) explanted cardiac allografts were significantly lower in sc28AT+hu5C8 group compared to sc28AT or hu5C8 monotherapy groups. Each dot represents the median of ISHLT scores for 1 tissue specimen. Multiple data points from individual animals over time are represented with a specific symbol, while symbol color identifies treatment group.