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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Transplantation. 2018 Mar;102(3):e90–e100. doi: 10.1097/TP.0000000000002044

Figure 2. Cardiac allograft vasculopathy.

Figure 2

(A) Representative vessel from a hu5C8-treated cardiac allograft (day 90, left panel) shows grade 2 cardiac allograft vasculopathy (CAV) with distinct neointimal thickening (10–50% luminal narrowing). In contrast, a representative artery from a sc28AT+hu5C8-treated graft (day 90, right panel) shows absence of neointimal proliferation (H&E staining, original magnification ×200). (B) CAV severity score for biopsy and functional (open boxes) or rejected (grey boxes) explanted cardiac allograft tissue specimens. CAV scores with sc28AT+hu5C8 (red) were significantly lower than with hu5C8 alone (green) during the first 3 months. Each data point represents the median of CAV scores for 1 tissue specimen. Multiple data points from individual animals over time are represented with a specific symbol, while symbol color identifies treatment group.