Correction to: Molecular Psychiatry (2017) advance online publication 14 February 2017; doi:10.1038/mp.2017.5
Following publication of this paper, the authors noticed a mistake in Tables 3 and 4 and Figure 3. The genetic correlation between tiredness and C-reactive protein was displayed as 0.0165, but the correct genetic correlation is 0.1650. The thresholds for major depressive disorder and neuroticism are incorrect in Table 4. The threshold for major depressive disorder is 0.1, and for neuroticism the threshold is 1. The corrected tables and figure appear below.
Table 3.
Genetic correlations between tiredness documented in the UK Biobank data set and the health-related variables collected from GWAS consortia
Trait category | Traits from GWAS consortia | rg | s.e. | P-value |
---|---|---|---|---|
Physical health | Blood pressure: diastolic | 0.0332 | 0.0502 | 0.5083 |
Blood pressure: systolic | −0.0698 | 0.0478 | 0.1444 | |
BMI | 0.2024 | 0.0322 | 3.18 × 10 −10 | |
Cholesterol: HDL | −0.1087 | 0.0373 | 0.0036 | |
Cholesterol: LDL | 0.0829 | 0.0413 | 0.0449 | |
Coronary artery disease | 0.1338 | 0.067 | 0.0459 | |
C-reactive protein | 0.1650 | 0.054 | 0.0021 | |
Grip strengtha | −0.1596 | 0.0482 | 0.0009 | |
HbA1c | 0.2536 | 0.0857 | 0.0031 | |
Height | −0.0201 | 0.0297 | 0.4980 | |
Longevity | −0.3943 | 0.1096 | 0.0003 | |
Forced expiratory volume 1sa | −0.1181 | 0.0538 | 0.0281 | |
Obesity | 0.2063 | 0.0381 | 6.31 × 10 −8 | |
Rheumatoid arthritis | −0.0181 | 0.0674 | 0.7885 | |
Self-rated healtha | −0.7780 | 0.0349 | 7.30 × 10 −110 | |
Smoking status | 0.2009 | 0.0603 | 0.0009 | |
Triglycerides | 0.1324 | 0.0332 | 6.62 × 10 −5 | |
Type 2 diabetes | 0.1784 | 0.0689 | 0.0097 | |
Waist–hip ratio | 0.2834 | 0.0417 | 1.09 × 10 −11 | |
Mental health | ADHD | 0.2694 | 0.1116 | 0.0158 |
Alzheimer's disease | 0.0762 | 0.1079 | 0.4801 | |
Alzheimer’s disease (500 kb) | 0.0613 | 0.0872 | 0.4816 | |
Anorexia nervosa | 0.0192 | 0.0492 | 0.6967 | |
Autism | 0.0129 | 0.0695 | 0.8522 | |
Bipolar disorder | 0.1382 | 0.0605 | 0.0223 | |
Childhood cognitive ability | −0.1528 | 0.0891 | 0.0864 | |
Major depressive disorder | 0.5902 | 0.1015 | 6.03 × 10 −9 | |
Neuroticism | 0.6150 | 0.038 | 7.34 × 10 −59 | |
Schizophrenia | 0.2490 | 0.0386 | 1.14 × 10 −10 | |
Verbal–numerical reasoninga | −0.1379 | 0.0596 | 0.0206 |
Abbreviations: ADHD, attention deficit hyperactive disorder; BMI, body mass index; GWAS, genome-wide association study; HbA1c, hemoglobin A1c; HDL, high-density lipoproteins; LDL, low-density lipoproteins; rg, genetic correlation; s.e., standard error.
Statistically significant P-values (after false discovery rate correction; threshold: P=0.0281) are shown in bold.
aGWAS based on UK Biobank data.
Table 4.
Associations between polygenic profile scores of health-related traits created from GWAS consortia summary data, and the UK Biobank tiredness phenotype controlling for age, sex, assessment centre, genotyping batch and array, and 10 principal components for population structure
Trait category | Trait | Threshold | β | P-value |
---|---|---|---|---|
Physical health | Blood pressure: diastolic | 0.1 | −0.0028 | 0.3619 |
Blood pressure: systolic | 0.1 | −0.0025 | 0.4077 | |
BMI | 1 | 0.0280 | 4.90 × 10−20a | |
Cholesterol: HDL | 0.5 | −0.0163 | 8.49 × 10−8a | |
Cholesterol: LDL | 0.5 | 0.0081 | 0.0077 a | |
Coronary artery disease | 0.5 | 0.0084 | 0.0061 | |
C-reactive protein | 1 | 0.0130 | 2.10 × 10−5a | |
Forced expiratory volume 1s | 0.01 | −0.0059 | 0.0529 | |
Longevity | 0.05 | −0.0067 | 0.0297 | |
HbA1c | 1 | 0.0090 | 0.0033 a | |
Height | 1 | −0.0077 | 0.0154 | |
Obesity | 1 | 0.0236 | 1.20 × 10−14a | |
Rheumatoid arthritis | 0.1 | −0.0016 | 0.5926 | |
Smoking status | 0.5 | 0.0086 | 0.0071 | |
Triglycerides | 0.5 | 0.0209 | 1.06 × 10−11a | |
Type 2 diabetes | 1 | 0.0120 | 0.0002a,b | |
Waist–hip ratio | 1 | 0.0258 | 7.85 × 10−17a | |
Mental health | ADHD | 1 | 0.0042 | 0.1647 |
Alzheimer’s disease | 0.05 | −0.0052 | 0.0889 | |
Anorexia nervosa | 0.5 | 0.0048 | 0.1169 | |
Autism | 1 | −0.0018 | 0.5593 | |
Bipolar disorder | 0.01 | 0.0081 | 0.0076 c | |
Childhood cognitive ability | 0.1 | −0.0112 | 0.0002 a | |
Major depressive disorder | 0.1 | 0.0185 | 2.25 × 10−9c | |
Neuroticism | 1 | 0.0183 | 2.00 × 10−9c | |
Schizophrenia | 1 | 0.0283 | 2.31 × 10−19a,c |
Abbreviations: ADHD, attention deficit hyperactive disorder; BMI, body mass index; GWAS, genome-wide association study; HbA1c, hemoglobin A1c; HDL, high-density lipoproteins; LDL, low-density lipoproteins.
False discovery rate-corrected statistically significant values (P=0.0255) are shown in bold. The associations between the polygenic profile scores with the largest effect size (threshold) and tiredness are presented. Threshold is the P-value threshold with the largest effect size.
aResults remain significant after controlling for neuroticism scores.
bResults remain significant after excluding individuals with type 2 diabetes (β=0.0105, P=0.00076).
cResults remain significant after controlling for self-rated health.
Figure 1.
Barplot of genetic correlations (s.e.) calculated using linkage disequilibrium score regression between tiredness in UK Biobank, and mental and physical health measures from GWAS consortia. *P< 0.0281. ADHD, attention deficit hyperactive disorder; BMI, body mass index; GWAS, genome-wide association study; HbA1c, hemoglobin A1c; HDL, high-density lipoproteins; LDL, low-density lipoproteins.
PowerPoint slides
Footnotes
The online version of the original article can be found at 10.1038/mp.2017.5