Appendix Table 1.

Test Characteristics of Colonoscopy and Fecal Immunochemical Tests (FIT)

	Tests
Test Characteristic	Colonoscopya	FITb
Specificity, %	0.86c	0.964
Sensitivity, %
Small adenomas (≤5mm)	0.75	0.076d
Medium adenomas (6-9 mm)	0.85	0.076d
Large adenomas (≥10 mm)	0.95	0.238e
CRCs that would not have been clinically detected in their current stage	0.95	0.625f
CRCs that would have been clinically detected in their current stage	0.95	0.886f
Reach	95% reaches the cecum; the reach of the remaining 5% is distributed uniformly over colon and rectum	Whole colon and rectum
Complication rate	Increases exponentially with ageg	0
Mortality rate	0.0000191h	0

^aThe sensitivity of colonoscopy for the detection of adenomas and CRC within the reach of the endoscope was obtained from a systematic review on miss rates seen in tandem colonoscopy studies³³;

^bFIT characteristics were based on a large US based study comparing multi-targeted Stool DNA with FIT in a screening setting³⁴;

^cSpecificity for colonoscopy is therefore based on an adenoma prevalence study of patients undergoing screening colonoscopy³⁶;

^dSensitivity for non-advanced adenomas (not reported separately for medium adenomas);

^eSensitivity for advanced adenomas (not reported for large adenomas);

^fThese estimates were found by calibrating our model outcomes to the per-person sensitivities given in the multi-targeted Stool DNA with FIT ³⁴;

^gAge-specific risks for complications of colonoscopy requiring a hospital admission or emergency department visit were obtained from a study by Warren et al³⁷;

^hThe mortality rate associated with colonoscopies with a polypectomy was derived by multiplying the risk for a perforation obtained from a study by Warren et al³⁷ by the risk for death given a perforation obtained from a study by Gatto et a ³⁵.