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(A) HEK293T(VEGFR2+) target cell killing by VEGFR2-specific FnCAR-YT cells or YT cells transduced with an irrelevant Fn3(CEA)CAR, at the indicated E:T ratios. (B) IFNgamma release by FnCAR-transduced or non-transduced YT cells in the presence (black bars) or absence (grey bars) of target HEK(VEGFR2+) cells. kCEA-28z CAR targeting an irrelevant surface molecule, CEA, was used as a negative control.
