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. 2018 Jan 15;9(10):8810–8822. doi: 10.18632/oncotarget.24256

Figure 5. Presurgical estrogen deprivation in patients with ER+ breast cancer decreases tumor cell proliferation and IGF-1R/IRS-1/IRS-2 expression.

Figure 5

A/B) Formalin-fixed, paraffin-embedded diagnostic tumor biopsies (baseline) and surgical specimens [post-letrozole (Arm B) or untreated (Arm A)] were analyzed by IHC using antibodies against Ki67 A. or PR B. *p<0.05 by Wilcoxon test. ns- not significant. C. Lysates from frozen surgical tumor specimens were analyzed by immunoblot using the indicated antibodies.