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(A) Mimic-1 is more potent then unmodified miR-129 on colon cancer cells. (B) The IC50 for Mimic-1 is 11.71 nM compared to 43.2 nM for miR-129. (C, D) Mimic-1 is more stable than miR-129. (E) Formation of the FdUMP-TS complex (the upper shift-band) with 5-FU released from the degraded Mimic-1 is shown by Western immunoblot. (**p<0.01).
