Figure 3. Inhibition of growth and colony-forming ability by downregulation of PRMT6 in CRC cell lines.

(A) Knockdown of endogenous PRMT6 in three CRC cell lines by siRNAs transfection. (B) Suppression of PRMT6 inhibits cell growth as determined by a WST-1 based assay. (C) Representative stained plates of the CRC cells are shown and (D) the number of colonies was evaluated. Error bars denote SEM from three independent experiments. ^*, p < 0.05; ^**, p < 0.01.