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. 2017 Mar 16;3(8):1069–1077. doi: 10.1001/jamaoncol.2017.0001

Brain Metastases in Newly Diagnosed Breast Cancer

A Population-Based Study

Allison M Martin 1, Daniel N Cagney 1, Paul J Catalano 2, Laura E Warren 1, Jennifer R Bellon 1, Rinaa S Punglia 1, Elizabeth B Claus 3,4, Eudocia Q Lee 5, Patrick Y Wen 5, Daphne A Haas-Kogan 1, Brian M Alexander 1, Nancy U Lin 6, Ayal A Aizer 1,
PMCID: PMC5824221  PMID: 28301662

Key Points

Question

What are the incidence and prognosis of patients with breast cancer and brain metastases at diagnosis?

Findings

In this population-based cohort study, patients with triple-negative and hormone receptor–negative human epidermal growth factor receptor 2–positive subtypes and metastatic disease to any distant site harbored the highest likelihood (11.37% and 11.45%, respectively) of presenting with brain metastases at diagnosis of breast cancer. The prognosis of patients with triple-negative disease was poorest (median survival, 6 months).

Meaning

Future studies evaluating the utility of screening brain magnetic resonance imaging among patients at high risk of brain metastases may be warranted.

Abstract

Importance

Population-based estimates of the incidence and prognosis of brain metastases at diagnosis of breast cancer are lacking.

Objective

To characterize the incidence proportions and median survivals of patients with breast cancer and brain metastases at the time of cancer diagnosis.

Design, Setting, and Participants

Patients with breast cancer and brain metastases at the time of diagnosis were identified using the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute. Data were stratified by subtype, age, sex, and race. Multivariable logistic and Cox regression were performed to identify predictors of the presence of brain metastases at diagnosis and factors associated with all-cause mortality, respectively. For incidence, we identified a population-based sample of 238 726 adult patients diagnosed as having invasive breast cancer between 2010 and 2013 for whom the presence or absence of brain metastases at diagnosis was known. Patients diagnosed at autopsy or with an unknown follow-up were excluded from the survival analysis, leaving 231 684 patients in this cohort.

Main Outcomes and Measures

Incidence proportion and median survival of patients with brain metastases and newly diagnosed breast cancer.

Results

We identified 968 patients with brain metastases at the time of diagnosis of breast cancer, representing 0.41% of the entire cohort and 7.56% of the subset with metastatic disease to any site. A total of 57 were 18 to 40 years old, 423 were 41 to 60 years old, 425 were 61-80 years old, and 63 were older than 80 years. Ten were male and 958 were female. Incidence proportions were highest among patients with hormone receptor (HR)-negative human epidermal growth factor receptor 2 (HER2)-positive (1.1% among entire cohort, 11.5% among patients with metastatic disease to any distant site) and triple-negative (0.7% among entire cohort, 11.4% among patients with metastatic disease to any distant site) subtypes. Median survival among the entire cohort with brain metastases was 10.0 months. Patients with HR-positive HER2-positive subtype displayed the longest median survival (21.0 months); patients with triple-negative subtype had the shortest median survival (6.0 months).

Conclusions and Relevance

The findings of this study provides population-based estimates of the incidence and prognosis for patients with brain metastases at time of diagnosis of breast cancer. The findings lend support to consideration of screening imaging of the brain for patients with HER2-positive or triple-negative subtypes and extracranial metastases.


This population-based cohort study uses the SEER database to characterize the incidence proportion of brain metastases at the time of cancer diagnosis among patients with breast cancer on a population-based level.

Introduction

Brain metastases represent a significant cause of morbidity and mortality among patients with breast cancer. Robust population-based estimates relating to the incidence of brain metastases at diagnosis of breast cancer are lacking, in part due to diagnosis coding schema that cannot specifically capture the presence or absence of brain metastases. In autopsy studies, 15% to 35% of patients with breast cancer are found to have brain metastases, not all of which are clinically apparent prior to death. The risk of brain metastasis is subtype-dependent, and patients with human epidermal growth factor receptor 2 (HER2)-positive and triple-negative subtypes experience significantly higher rates of central nervous system (CNS) relapse than patients with hormone receptor (HR)-positive HER2-negative tumors. Based on a lack of proven benefit, current breast cancer screening guidelines, in patients with both localized and metastatic disease, do not recommend routine assessment or continued reassessment of brain metastases via imaging of the brain. Thus, most brain metastases in patients with breast cancer are detected because of neurologic symptoms, often necessitating interventions such as neurosurgical resection and/or whole brain radiation.

Population-level estimates for prognosis among patients with newly diagnosed breast cancer and brain metastases are also lacking. Data from single institution experiences and prospective studies have yielded varying results. Triple-negative subtype seems to be associated with a poorer prognosis. Other sociodemographic and clinical predictors of outcome, on a population level, have not been well characterized.

The purpose of this study was to use the Surveillance, Epidemiology, and End Results (SEER) database to characterize the incidence proportion of brain metastases at the time of cancer diagnosis among patients with breast cancer on a population-based level. We also sought to quantify survival estimates and to examine clinical and sociodemographic predictors of poorer survival among patients with breast cancer and brain metastases present at diagnosis of breast cancer.

Methods

The SEER database includes information on cancer incidence, treatment, and survival for approximately 30% of the US population. Information on the presence or absence of brain metastases at the time of initial cancer diagnosis was released in 2016 for patients diagnosed as having systemic malignant disease from 2010 to 2013. Within the SEER database, we identified 246 343 patients 18 years or older who were diagnosed as having a primary, invasive breast cancer between January 1, 2010, and December 31, 2013. Patients with carcinoma in situ were not included in the cohort. Patients for whom the presence or absence of brain metastases at diagnosis was unknown were excluded, leaving 238 726 patients in the final cohort for incidence analysis. Of these, 968 patients were diagnosed as having brain metastases. We subsequently removed patients who were diagnosed at autopsy or via death certificate, as well as patients who had an unknown follow-up, leaving 848 patients eligible for survival analysis. This study was approved by the institutional review board at Dana Farber Cancer Institute, and written informed consent was waived.

Patients were stratified by breast cancer subtype: HR-positive HER2-negative, HR-positive HER2-positive, HR-negative HER2-positive, and triple-negative (HR-negative HER2-negative). Absolute numbers and incidence proportions were calculated for patients with breast cancer with brain metastases identified at diagnosis; incidence proportions were also calculated after stratification by age, race, and sex. Incidence proportion was defined as the number of breast cancer patients diagnosed as having brain metastases divided by the total number of patients with breast cancer. Incidence proportion was also computed among patients with metastatic disease to any distant site. Race/ethnicity was categorized as white, black, Hispanic, Asian American, or other according to the SEER database.

Multivariable logistic regression was used to determine whether age, race/ethnicity, and sex were associated with the presence of brain metastases at diagnosis; other variables in the model included marital status, insurance status, residence type (urban vs rural), education, median household income, breast cancer subtype, and the extent of systemic disease at diagnosis. Residence type, education level (ie, percentage of adults ≥25 years with a high school education), and median household income were determined at the county level by linkage to the 2003 US Department of Agriculture rural-urban continuum codes, 2000 US Census, and 2004 small area income and poverty estimates from the US Census, respectively. The presence of bone, lung, and liver metastases at diagnosis is available in the SEER database and was used to characterize the extent of systemic disease among patients in this study.

Survival estimates were obtained using the Kaplan-Meier method. Multivariable Cox regression was performed to identify covariates associated with increased all-cause mortality using the same variables as in the logistic regression model described herein. To assess breast cancer–specific mortality, we used Fine and Gray’s competing risk regression. The hazard function for patients with unknown subtype was nonproportional over time, and therefore we included the interaction between this covariate and time in the model. Statistical analyses were performed using SAS statistical software (version 9.4; SAS Institute Inc) with the exception of the competing risks analysis, which was performed in R (version 3.3.2; R Foundation) using the cmprsk package (version 2.2-72014).

Results

Incidence

Among the 238 726 patients with breast cancer analyzed for incidence, 67.9%, 9.4%, 4.1%, 10.6%, and 8.0% had HR-positive HER2-negative, HR-positive HER2-positive, HR-negative HER2-positive, triple-negative, and unknown subtypes, respectively. Among the cohort with metastatic disease to any site (n = 12 801), 51.6%, 13.3%, 7.2%. 11.9%, and 16.0% had HR-positive HER2-negative, HR-positive HER2-positive, HR-negative HER2-positive, triple-negative, and unknown subtypes, respectively. The number and incidence proportions of patients with breast cancer and identified brain metastases at diagnosis are provided in Table 1, as stratified by breast cancer subtype. Among the entire cohort, 968 patients presented with brain metastases, reflecting 0.41% of the entire study population and 7.56% of the subset with metastatic disease at any site. Incidence proportions were highest among patients with HR-negative HER2-positive (1.1% of the entire cohort, 11.5% of the metastatic subset) and triple-negative (0.7% of the entire cohort, 11.4% of the metastatic subset) subtypes.

Table 1. Incidence Proportion and Median Survival of Patients With Breast Cancer With Identified Brain Metastases at Diagnosis by Subtype.

Subtype Patients, No. Incidence Proportion of Brain Metastases, % Survival Among Patients With Brain Metastases, Median (IQR), mo
With Breast Cancer With Metastatic Disease With Brain Metastases Among Entire Cohort Among Subset With Metastatic Disease
HR+/HER2 162 078 6607 361 0.22 5.46 14.0 (4.0-34.0)
HR+/HER2+ 22 376 1704 136 0.61 7.98 21.0 (6.0-NR)
HR/HER2+ 9719 926 106 1.09 11.45 10.0 (4.0-27.0)
Triple-negative 25 362 1522 173 0.68 11.37 6.0 (2.0-13.0)
Unknown 19 191 2042 192 1.00 9.40 6.0 (2.0-20.0)
All subtypes 238 726 12 801 968 0.41 7.56 10.0 (3.0-30.0)

Abbreviations: HER2, human epidermal growth factor receptor 2; HR, hormone receptor; IQR, interquartile range; NR, not reached. + Denotes positive; − denotes negative.

On multivariable logistic regression (Table 2) among patients with metastatic cancer, age 41 to 60 years (vs age 18-40 years; odds ratio [OR], 1.41; 95% CI, 1.05-1.88; P = .02) and age 61 to 80 years (vs age 18-40 years; OR, 1.40; 95% CI, 1.04-1.88; P = .03), metastatic disease to 2 extracranial sites (vs 0 or 1 site; OR, 1.65; 95% CI, 1.41-1.94; P < .001) or 3 extracranial sites (vs 0 or 1 site; OR, 3.40; 95% CI, 2.76-4.18; P < .001), and HR-positive HER2-positive (vs HR-positive HER2-negative subtype; OR, 1.41; 95% CI, 1.14-1.73; P = .001), HR-negative HER2-positive (vs HR-positive HER2-negative subtype; OR, 2.09; 95% CI, 1.66-2.64; P < .001), and triple-negative subtypes (vs HR-positive HER2-negative subtype; OR, 2.19; 95% CI, 1.81-2.66; P < .001) were associated with significantly greater odds of having brain metastases at diagnosis. Neither race nor income was associated with a risk of brain metastasis at diagnosis in the multivariable model. Insured status was associated with marginally lower odds of brain metastasis at diagnosis (OR, 0.77; 95% CI, 0.58-1.00; P = .05). Significant results are presented in Table 2.

Table 2. Multivariable Logistic Regression for the Presence of Brain Metastases at Diagnosis of Breast Cancera.

Variable Patients, No. Among Entire Cohort Among Subset With Metastatic Disease
Patients
(n = 238 726)
With Brain Metastases
(n = 968)
OR (95% CI) P Value OR (95% CI) P Value
Age at diagnosis, yb
18-40 13 564 57 1 [Reference] NA 1 [Reference] NA
41-60 98 184 423 NA NA 1.41 (1.05-1.88) .02
61-80 103 700 425 NA NA 1.40 (1.04-1.88) .03
>80 23 265 63 NA NA NA NA
Sex
Male 1854 10 1 [Reference] NA 1 [Reference] NA
Female 236 872 958 NA NA NA NA
Raceb
White 165 808 603 1 [Reference] NA 1 [Reference] NA
Black 25 914 187 1.27 (1.06-1.53) .01 NA NA
Hispanic 25 359 121 NA NA NA NA
Asian 19 043 53 NA NA NA NA
Other 1688 4 NA NA NA NA
Marital status
Unmarried 97 199 526 1 [Reference] NA 1 [Reference] NA
Married 127 644 389 0.73 (0.63-0.84) <.001 NA NA
Unknown 13 883 53 NA NA NA NA
Median household income (per $10 000 annual increase) 238 726 968 NA NA NA NA
High school education (per 10% increase) 238 726 968 NA NA NA NA
Insurance status
Uninsured 4446 68 1 [Reference] NA 1 [Reference] NA
Insured 229 369 876 0.60 (0.45-0.79) <.001 0.77 (0.58-1.00) .05
Unknown 4911 24 NA NA NA NA
Urban
Rural 25 454 117 1 [Reference] NA 1 [Reference] NA
Urban 212 934 851 NA NA NA NA
Extracranial metastatic sites to bone, lung, and liver, No.
0 or 1 234 640 502 1 [Reference] NA 1 [Reference] NA
2 2755 252 37.35 (31.78-43.90) <.001 1.65 (1.41-1.94) <.001
All 3 777 139 75.12 (60.82-92.80) <.001 3.40 (2.76-4.18) <.001
Unknown 554 75 57.17 (43.84-74.56) <.001 3.90 (2.98-5.12) <.001
Subtype
HR+/HER2 162 078 361 1 [Reference] NA 1 [Reference] NA
HR+/HER2+ 22 376 136 1.92 (1.57-2.37) <.001 1.41 (1.14-1.73) .001
HR/HER2+ 9719 106 3.25 (2.57-4.09) <.001 2.09 (1.66-2.64) <.001
Triple-negative 25 362 173 2.61 (2.16-3.15) <.001 2.19 (1.81-2.66) <.001
Unknown 19 191 192 2.68 (2.22-3.24) <.001 1.74 (1.44-2.10) <.001

Abbreviations: HER2, human epidermal growth factor receptor 2; HR, hormone receptor; OR, odds ratio. + Denotes positive; − denotes negative.

a

Only significant results presented (P < .05).

b

Unknown age and unknown race removed from model owing to nonconvergence (n = 920).

Survival

Median survival among patients in the survival cohort with breast cancer and identified brain metastases at diagnosis who were not diagnosed at autopsy or via death certificate and who had a defined period of follow-up (n = 848), as stratified by subtype, is presented in Table 1. The median survival among the entire cohort was 10.0 months, with patients with HR-positive HER2-positive subtype experiencing the longest median survival (21.0 months) and patients with triple-negative subtype experiencing the shortest median survival (6.0 months). Survival estimates overall (Figure, A) and as stratified by subtype (Figure, B) and by extent of extracranial metastatic disease (Figure, C) are graphically displayed in the Figure.

Figure. Overall Survival Among Patients With Breast Cancer and Brain Metastases at Diagnosis.

Figure.

Extent of extracranial metastatic disease is classified by the number of metastatic sites to the bone, lung, or liver. HER2 denotes human epidermal growth factor receptor 2; HR, hormone receptor. + Denotes positive; − denotes negative.

On multivariable Cox regression (Table 3) for all-cause mortality among patients with brain metastases at diagnosis, age 41 to 60 years (vs age 18-40 years; hazard ratio, 1.70; 95% CI, 1.08-2.66; P = .02), age 61 to 80 years (vs age 18-40 years; hazard ratio, 2.28; 95% CI, 1.46-3.56; P < .001), and age greater than 80 years (vs age 18-40 years; hazard ratio, 2.45; 95% CI, 1.52-4.25; P = .002), black race (vs white; hazard ratio, 1.34; 95% CI, 1.06-1.69; P = .01), unmarried social status (vs married social status; hazard ratio, 1.21; 95% CI, 1.01-1.47; P = .04), metastatic disease to 3 extracranial sites (vs 0 or 1 site; hazard ratio, 1.42; 95% CI, 1.08-1.85; P = .01), and triple-negative subtype (vs HR-positive HER2-negative subtype; hazard ratio, 1.98; 95% CI, 1.56-2.50; P < .001) were significantly associated with an increased all-cause mortality. HR-positive HER2-positive subtype was significantly associated with a decreased all-cause mortality (vs HR-positive HER2-negative subtype; hazard ratio, 0.71; 95% CI, 0.53-0.95; P = .02). Breast cancer–specific mortality among patients with breast cancer and brain metastases at diagnosis is also presented in Table 3. Table 4 displays median survival by subtype as stratified by the extent of systemic disease. In general, survival was poorer among patients with more extensive systemic disease at diagnosis. We also found that the presence of brain metastases at initial diagnosis was associated with shorter survival time compared with patients presenting with de novo metastatic disease without baseline brain involvement (Table 4).

Table 3. Multivariable Cox Regression for All-Cause Mortality and Breast Cancer–Specific Mortality Among Patients With Brain Metastasesa.

Variable Patients, No. All-Cause Mortality Breast Cancer–Specific Mortality
Patients
(n = 231 684)
With Brain Metastases
(n = 968)
Hazard Ratio (95% CI) P Value Hazard Ratio (95% CI) P Value
Age at diagnosis, yb
18-40 13 564 57 1 [Reference] NA 1 [Reference] NA
41-60 98 184 423 1.70 (1.08-2.66) .02 NA NA
61-80 103 700 425 2.28 (1.46-3.56) <.001 1.72 (1.11-2.68) .02
>80 23 265 63 2.45 (1.41-4.25) .002 NA NA
Sex
Male 1854 10 1 [Reference] NA 1 [Reference] NA
Female 236 872 958 NA NA 0.42 (0.19-0.94) .03
Raceb
White 165 808 603 1 [Reference] NA 1 [Reference] NA
Black 25 914 187 1.34 (1.06-1.69) .01 1.38 (1.09-1.74) .008
Hispanic 25 359 121 NA NA NA NA
Asian 19 043 53 NA NA NA NA
Other 1688 4 NA NA NA NA
Marital status
Unmarried 97 199 526 1 [Reference] NA 1 [Reference] NA
Married 127 644 389 0.82 (0.68-1.00) .04 0.72 (0.59-0.89) .002
Unknown 13 883 53 NA NA NA NA
Median household income (per $10 000 annual increase) 238 726 968 NA NA NA NA
High school education (per 10% increase) 238 726 968 NA NA NA NA
Insurance status
Uninsured 4446 68 1 [Reference] NA 1 [Reference] NA
Insured 229 369 876 NA NA NA NA
Unknown 4911 24 NA NA NA NA
Urban
Rural 25 454 117 1 [Reference] NA 1 [Reference] NA
Urban 212 934 851 NA NA NA NA
Extracranial metastatic sites to bone, lung, and liver, No.
0 or 1 234 640 502 1 [Reference] NA 1 [Reference] NA
2 2755 252 NA NA NA NA
All 3 777 139 1.42 (1.08-1.85) .01 NA NA
Unknown 554 75 NA NA NA NA
Subtypeb
HR+/HER2 162 078 361 1 [Reference] NA 1 [Reference] NA
HR+/HER2+ 22 376 136 0.71 (0.53-0.95) .02 NA NA
HR/HER2+ 9719 106 NA NA NA NA
Triple-negative 25 362 173 1.98 (1.56-2.50) <.001 1.69 (1.33-2.14) <.001
Unknown 19 191 192 2.42 (1.69-3.47) <.001 2.22 (1.39-0.74) <.001

Abbreviations: HER2, human epidermal growth factor receptor 2; HR, hormone receptor. + Denotes positive; − denotes negative.

a

Only significant results presented (P < .05).

b

Unknown age and unknown race removed from model due to nonconvergence (n = 745); model includes interaction between unknown subtype and time.

Table 4. Median Survival of Breast Cancer Patients by Extent of Systemic Metastatic Disease.

Subtype Type of Metastasis Survival, Median (IQR), mo
Extracranial Systemic Disease Only Extracranial Systemic Disease and Brain Metastases
HR+/HER2 Lung 42.0 (15.0-NR) 18.0 (2.0-36.0)
Liver 30.0 (10.0-NR) 9.0 (2.0-18.0)
Bone 39.0 (21.0-NR) 15.0 (6.0-31.0)
2 of 3 28.0 (11.0-NR) 16.0 (5.0-37.0)
All 3 18.0 (6.0-39.0) 12.0 (4.0-NR)
HR+/HER2+ Lung NR (21.0-NR) 18.0 (10.0-NR)
Liver NR (19.0-NR) NR (NR-NR)
Bone 46.0 (25.0-NR) 29.0 (12.0-NR)
2 of 3 34.0 (16.0-NR) 17.0 (4.0-NR)
All 3 24.0 (6.0-NR) 12.0 (6.0-NR)
HR/HER2+ Lung 25.0 (14.0-NR) 9.0 (4.0-17.0)
Liver NR (12.0-NR) 6.0 (4.0-6.0)
Bone NR (13.0-NR) NR (8.0-NR)
2 of 3 28.0 (10.0-NR) 9.0 (5.0-NR)
All 3 19.0 (8.0-NR) 11.0 (3.0-16.0)
Triple-negative Lung 14.0 (5.0-29.0) 7.0 (2.0-9.0)
Liver 14.0 (5.0-27.0) NR (3.0-NR)
Bone 14.0 (5.0-32.0) 11.0 (4.0-15.0)
2 of 3 10.0 (5.0-17.0) 5.0 (3.0-7.0)
All 3 5.0 (2.0-13.0) 5.0 (1.0-12.0)
Unknown Lung 16.0 (4.0-38.0) 9.0 (2.0-20.0)
Liver 18.0 (4.0-NR) 1.0 (1.0-9.0)
Bone 28.0 (8.0-47.0) 12.0 (2.0-19.0)
2 of 3 15.0 (5.0-33.0) 12.0 (1.0-18.0)
All 3 12.0 (3.0-28.0) 2.0 (1.0-7.0)
All subtypes Lung 25.0 (10.0-NR) 8.0 (2.0-19.0)
Liver 29.0 (9.0-NR) 9.0 (3.0-27.0)
Bone 37.0 (17.0-NR) 14.0 (4.0-35.0)
2 of 3 24.0 (9.0-NR) 10.0 (3.0-34.0)
All 3 16.0 (5.0-35.0) 7.0 (2.0-27.0)

Abbreviations: HER2, human epidermal growth factor receptor 2; HR, hormone receptor; IQR, interquartile range; NR, not reached. + Denotes positive; − denotes negative.

Discussion

In this study, we describe the incidence of identified brain metastases among patients with newly diagnosed breast cancer and characterize the subsequent survival of such patients. We found that the incidence proportion of brain metastases was highest among patients with HR-negative HER2-positive and triple-negative subtypes. Patients in the incidence cohort were likely diagnosed as a result of neurologic symptoms given that consensus guidelines for patients with breast cancer do not recommend screening imaging of the brain. As a result, the true incidence of brain metastases in patients with breast cancer is likely underestimated by the results in this study. Notably, median survival from diagnosis varied significantly by subtype, ranging from 6.0 months in patients with triple-negative breast cancer to 21.0 months in patients with HR-positive HER2-positive breast cancer. Because SEER data include approximately 30% of the United States population, the incidence proportions and median survivals we describe are highly generalizable and likely more reflective of the population experience compared with previously published data focused primarily on patients treated at academic cancer centers. In addition, we report for the first time, to our knowledge, population-based survival outcomes by tumor subtype among patients with brain metastases on initial breast cancer presentation.

Barnholtz-Sloan et al previously reported on the incidence proportion of patients with multiple different cancers who were diagnosed as having brain metastases from 1973 to 2001 in the Metropolitan Detroit, Michigan, area. They found a cumulative incidence of identified brain metastases among patients with breast cancer (all stages at diagnosis) of 5.1%. Among patients with breast cancer with distant metastases to any systemic site, 14.2% developed brain metastases during their disease course. A strength of the study was the availability of information regarding the incidence of brain metastases that developed at any time over the disease course, as opposed to at first presentation, as in our study. However, tumor subtype was not available, and outcomes were not reported. Also, because the data were limited to only 3 counties near Detroit, the results may be less generalizable to the United States at large. Pelletier et al estimated the cumulative incidence over time of brain metastases among patients with breast cancer from a US commercial insurance claims database from 2002 to 2004. They found an incidence of 9.1% among the entire cohort. The study included only patients who made insurance claims, and results were not stratified by subtype. Similar population-based studies have been conducted outside the United States, finding cumulative incidence proportions ranging from 3.4% to 5.0% in the Netherlands, Germany, and Finland.

In contrast to most of the published experience on this topic, our work focuses on patients presenting with de novo metastatic breast cancer. Our results confirm and extend previous work describing the interaction between tumor subtype and the risk of brain metastases among patients initially presenting with stage I to III breast cancer. In a Canadian study of 3726 patients diagnosed as having early-stage breast cancer from 1986 to 1992 with a median follow-up time of 14.8 years, Kennecke et al reported cumulative incidence proportions of brain metastases for luminal A, HER2-positive and estrogen receptor–positive progesterone receptor–positive, HER2-positive, and nonbasal triple-negative subtypes of 2.2%, 7.9%, 14.3%, and 7.2%, respectively, among all patients. Among the patients who developed metastatic disease, the cumulative incidence proportions were 7.6%, 15.4%, 28.7%, and 22.0%, respectively. More contemporary studies have reported lifetime incidence proportions for the development of brain metastases among patients with HER2-positive and triple-negative metastatic breast cancer as high as 34% to 55% and 22% to 46%, respectively.

Current National Comprehensive Cancer Network (NCCN), American Society of Clinical Oncology, and European School of Oncology-Metastatic Breast Cancer guidelines for breast cancer do not include the use of routine brain screening of brain metastases in asymptomatic patients, based on a lack of demonstrated survival advantage in nonrandomized retrospective studies. During the time period analyzed (2010-2013), screening brain magnetic resonance imaging (MRI) for stage II-IV non–small-cell lung cancer was considered standard practice, based on NCCN guidelines. The recommendation of brain MRI at initial lung cancer diagnosis was added following the publication of various studies suggesting its potential benefit among selected patients with lung cancer. Kim et al found an incidence of brain metastases of 20.8% for the patients with NSCLC who were screened with brain MRI vs 4.6% for nonscreened patients. We found that 7.56% of patients with metastatic breast cancer to any site had brain metastases at diagnosis; presumably, these patients were symptomatic given the lack of routine screening in patients with breast cancer. When metastases are identified early, they are typically amenable to potentially less toxic approaches, such as stereotactic radiosurgery or use of systemic agents with intracranial penetration. Whether routine CNS staging in patients with metastatic breast cancer could reduce the need for neurosurgical resection, whole-brain radiation, or a higher neurologic death rate is not known at this time; our results support the need for further investigation of this very common clinical question.

Among the entire cohort, black patients (vs white patients) had significantly greater odds of having brain metastases at diagnosis (OR, 1.27; 95% CI, 1.06-1.53; P = .01), but this association was not seen among the cohort with metastatic disease to any distant site. This suggests but does not prove that breast cancers in black patients are likely being diagnosed at a later stage than in white patients. A greater cause for concern is that we found that black patients with brain metastases had worse overall median survival, with a significant hazard ratio of 1.34 (95% CI, 1.06-1.69; P = .01) despite adjustment for sociodemographic factors, insurance status, extent of systemic disease, and subtype. Further study evaluating potential explanations for this finding is warranted. Our group has previously found a significant increase in the hazard ratio (1.37 to 1.53; P interaction <.001) for all-cause mortality among black vs white patients with localized breast cancer from the 1988-1997 to 1998-2007 time periods, suggesting that outcomes in the black patients with breast cancer are worsening with time. It remains unclear if there is tumor biology, access to care, or another etiology is driving this trend, and further investigation is warranted.

We found that median survival for patients with breast cancer with brain metastases varied significantly by subtype, with triple-negative breast cancer being associated with the poorest survival (median survival, 6.0 months). HR-positive HER2-positive patients had the longest survival (median survival, 21.0 months). Our data are consistent with some of the general trends reported in academic center–based retrospective studies. Importantly, given the potential referral bias and other biases that can be present in academic center–based series, we confirmed in a population-based sample of patients with newly diagnosed breast cancer and brain metastases that indeed, contrary to historical data, a median survival of nearly 2 years after diagnosis is now achieved in patients with HR-positive HER2-positive tumors. Our data support the importance of strategies to avoid long-term neurotoxic effects of CNS-directed treatments in such patients, as well as the importance of strategies to manage CNS progression events in patients with diagnosed brain metastases at the time of primary cancer diagnosis with relatively extended survival. We also found that the presence of brain metastases at initial diagnosis was associated shorter survival time compared with patients presenting with de novo metastatic disease without baseline brain involvement.

Limitations

Our study should be considered in the context of its limitations. First, we were able to describe only the presence vs absence of brain metastases at initial diagnosis. The SEER database does not provide information about disease recurrence or subsequent sites of disease involvement; thus, we were unable to comment on patients who developed brain metastases later in their disease course. Therefore, there may be some patients who subsequently developed brain metastases later in the disease course who would not be captured in our analysis. Future studies using alternative data sources should be carried out to address this important point. Second, because breast cancer screening guidelines do not recommend use of brain MRI for screening, many patients presenting with brain metastases at diagnosis were likely symptomatic. Therefore, we likely underestimated the actual rate of brain metastases in patients with newly diagnosed breast cancer. It is unclear from the data what the incidence might be for patients without neurologic symptoms. In addition, the threshold for obtaining imaging of the brain may have varied among different institutions and practitioners. Third, residence type, education level, and median household income were defined at a county level, not a patient level, possibly affecting the results of the logistic and Cox regressions. Fourth, information relating to comorbidities, performance status, and smoking status is not available in the SEER database. Finally, we cannot comment on the treatment that patients with brain metastases received given that such information is not recorded in the SEER database.

Conclusions

Despite these limitations, our study provides insight into the epidemiology of brain metastases in patients with newly diagnosed breast cancer in the United States. It lends support to consideration of studies evaluating the utility of screening MRI of the brain among patients at high risk of brain metastases, including those with HER2-positive or triple-negative disease and other systemic metastases. The degree to which earlier diagnosis may have an impact on important outcomes such as brain-directed neurosurgical or radiotherapeutic treatment, quality of life, and cost-effective care, warrants further investigation.

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