Figure 1. Hippo signaling pathway gene NF2 is altered in 22.5% of PRCC.

(A) Cartoon depicting the Hippo signaling pathway and how Merlin (encoded by NF2) and tyrosine-protein kinase Yes play a role in this pathway. (B) Mutation and deletion of NF2 in the TCGA cohort of 280 PRCC tumors (Data downloaded for cBioPortal [17, 18]). (C) Survival of patients with NF2 altered PRCC tumors compared to NF2 unaltered PRCC tumors.