Gingival complex odontoma: a rare case report with a review of the literature

Abstract

Odontomas are odontogenic tumors composed of a mixture of dental tissues. They are very common hamartomas of the jaws. However, their peripheral or gingival counterparts are extremely uncommon. The objective of this article is to report a rare case of gingival complex odontoma in an 11-year-old patient, and also to review all published cases of this type of lesion.

INTRODUCTION

Odontomas are odontogenic tumors/hamartomas composed of dental tissue in a variable proportion. They are classically divided into compound or complex types, and are much more common in children and young adults. In most cases, odontomas are intraosseous and disturb the eruption of both permanent and deciduous teeth.¹ In a few cases, they may erupt in the oral cavity.² However, such lesions rarely develop completely within tooth-bearing soft tissues, but, in this case, they may be called gingival or peripheral odontomas.³

Gingival odontoma is almost never diagnosed as such when making a differential diagnosis of peripheral lesions. Given its rare occurrence, we thought it important to report the case of a gingival complex odontoma, and also considered it pertinent to review all published cases since the first report of this type of odontoma in 1989.

CASE REPORT

An 11-year-old white female patient was referred to the Stomatology clinic of the University of São Paulo, because of a painless nodular lesion on the palatal gingiva close to the incisive papilla. The nodule was sessile, smooth-surfaced, covered with normal colored mucosa, firm upon palpation and measured approximately 1.5 cm (Figure 1).

Figure 1. Clinical presentation showing a nodular lesion on the palatal aspect between maxillary left permanent central and lateral incisors.

The patient reported that the lesion had grown slowly over 2 years. The clinical hypothesis included peripheral ossifying fibroma and peripheral giant cell granuloma, and the patient was submitted to an excisional biopsy. The absence of bone erosion was confirmed through radiographic examination and during surgery.

In the course of gross examination, a hard consistency was noticed and the specimen was sent to be decalcified. The microscopic analysis revealed the presence of a rounded lesion within the lamina propria composed of randomly arranged dental tissues (Figure 2A). The tissues were mostly young, and composed of tubular dentin, cementum-like material and loosely arranged mesenchymal cells resembling dental papilla. The mass contained odontoblast-like cells adjacent to the dentin, small islands of odontogenic epithelium and few basophilic areas interpreted as enamel matrix. Foci of ghost cells were also observed (Figure 2B). The final diagnosis was peripheral complex odontoma.

Figure 2. Photomicrograph of the excisional biopsy showing in A – a tumor composed of dental tissues within the lamina propria (H&E, 25X), and in B – mesenchymal cells loosely arranged resembling dental papilla (DP), odontogenic epithelium (Ep), cementum-like material (C), tubular dentin (D), enamel matrix (white arrows), and ghost cells (black arrows) (H&E, 100X).

The surgery site healed uneventfully, and the patient remains lesion-free after one year.

DISCUSSION

Odontogenic tumors make up a large group of neoplastic and developmental lesions originating from the odontogenic epithelium, the ectomesenchyme or both. Because tooth formation takes place within the jaw bones, it is reasonable to expect that the tumors developing there will be only intraosseous. Nevertheless, occasionally rests of dental lamina (rests of Serres) entrapped within gingival tissues may give rise to peripheral odontogenic tumors.⁴ There is still no consensus regarding what stimuli could activate the rests of dental lamina and initiate formation of a gingival odontoma.⁵ As the intraosseous counterpart of peripheral odontogenic tumors, gingival odontomas are also divided into compound or complex types, based upon their histopathological features.^6-11 Some authors prefer to classify them as peripheral developing odontomas instead,^12-14 a misused term since the lesion is hamartomatous by definition.

Microscopic analysis of our case revealed different amounts of dental tissue within the palatal gingiva, without any connection to underlying bone or overlying epithelium. Some pathologists may not feel very comfortable in distinguishing an epithelium-rich odontoma from an ameloblastic fibro-odontoma, due to their histological similarities. Indeed, most authors believe these lesions are different parts of the same spectrum that comprises a hamartomatous variant and a truly neoplastic ameloblastic fibroma.¹⁵ In this case, the dental tissues appeared well circumscribed and ball-shaped, closely resembling an intraosseous tumor. This arrangement served as strong evidence to establish the diagnosis as that of a peripheral odontoma, and not an ameloblastic fibro-odontoma.¹⁶ Moreover, our case failed to demonstrate enamel organ-like islands typically seen in fibro-odontoma.

Some authors also consider a supernumerary tooth as a different expression of the same pathological process that leads to odontoma.^14,17 This histological appearance of a disorganized developing dental germ observed in both lesions could support such a hypothesis. However, even though this idea may be applicable to some situations, supernumeraries do not cause a slow growing mass, as was observed in this case report.

Gingival odontoma may also erupt in the oral cavity if left untreated.¹⁸ It is unclear if eruption is a trend for all cases, but it may be related to tumor growth over time or to local bone resorption.¹⁸ The absence of resorption noted during the surgery, and the distance between the tumor in relation to the surface epithelium strongly suggests that eruption would hardly come about in this patient.

Table 1 presents all the previously published diagnosed cases of this tumor. The research included the terms “peripheral odontoma”, “gingival odontoma” and “soft tissue odontoma” as key words in PUBMED, MEDLINE, COCHRANE and GOOGLE SCHOLAR databases, and resulted in 15 papers dating from 1989 to 2014. Four of them were available only at the public library of the University of São Paulo.^6-9 We excluded one article from the list because its authors were unable to decide whether the tumor was a peripheral ameloblastic fibro-odontoma or an odontoma, even though they did present some evidence pointing to the latter.¹⁶ This article reflected how hard is to distinguish between these lesions, as discussed earlier.

Table 1. Data from previously reported and present cases of gingival odontoma arranged by age.

Age*	Gender	Location (Tooth-bearing regions)**	Country	Histopathology	Reference
5 months	M	Maxilla, palatal aspect of F	Guatemala	Developing odontoma	Silva et al.14
8 months	M	Maxilla, anterior alveolar mucosa	Brazil	Developing odontoma	Silva et al.14
9 months	M	Maxilla, palatal aspect between 8-9	Japan	Developing odontoma	Mikami et al.19
2 years	F	Maxilla, posterior alveolar mucosa	USA	Complex odontoma	Ilief-Ala et al.10
3 years	F	Mandible, lingual aspect between M-L	México	Compound odontoma	Ledesma-Montes et al.6
3 years	M	Maxilla, palatal aspect between A-B	Germany	Developing odontoma	Friedrich et al.13
5 years	F	Maxilla, palatal aspect of J	USA	Compound odontoma	Giunta and Kaplan7
6 years	M	Mandible, lingual aspect of K	USA	Compound odontoma	Castro et al.8
7 years	M	Maxilla, labial aspect of 7	India	Complex odontoma	Siar and Nor9
7 years	F	Mandible, lingual aspect of 26	Japan	Developing odontoma	Ide et al.12
11 years	F	Maxilla, lingual aspect between 9-10	Brazil	Complex odontoma	Present case
12 years	M	Maxilla, labial aspect of 10	Brazil	Compound odontoma	Bernardes et al.4
13 years	F	Maxilla, palatal aspect between 7-8	Thailand	Developing odontoma	Kintarak et al.3
15 years	F	Maxilla, labial aspect between 10-11	Brazil	Compound odontoma	Hanemann et al.18
15 years	M	Maxilla, labial aspect between 9-10	India	Complex odontoma	Koneru et al.11
21 years	M	Mandible, buccal aspect between 30-31	USA	Compound odontoma	Giunta and Kaplan7
39 years	M	Maxilla, labial aspect between 10-11	Japan	Complex odontoma	Ide et al.20

^*Age at the first dental visit;

^**Tooth identification number follows the Universal Numbering System.

Similar to the descriptions of most reports, the present case was asymptomatic and showed no recurrence after surgical removal. The patient’s age at the time of diagnosis was approximately two years older than the average age for gingival odontoma. Some of the listed tumors showed unusual characteristics, such as ghost cells seen during histopathological examination,⁴ adult involvement and association with a congenital teratomatous tumor.^19,20 Foci of ghost cells were detected in these cases but their origin remains uncertain since these cells may appear in a variety of odontogenic tumors.

This is the fourth case reported in a Brazilian patient and the seventeenth case worldwide. We considered it relevant to report the present case, because it was an extremely rare odontogenic tumor, and enabled us to broaden our understanding of the clinicopathological features of this tumor.

INFORMED CONSENT

The informed consent was signed by the patient’s guardian.