Table 3.

List of databases of metabolic pathways

Acronym	Full name	Features	Reference
BiGG	Biochemical genetic and genomic knowledgebase of large scale metabolic reconstructions	A genome-scale metabolic reconstruction of the human metabolism	Schellenberger et al. (2010)
BioCyc	BioCyc database collection	A collection of computationally predicted metabolic pathways for nearly 9400 organisms whose genome is available Requires subscription	Caspi et al. (2016)
HumanCyc	Encyclopedia of human genes and metabolism	A partially curated database of metabolic reactions derived from the human genome Requires subscription	Romero et al. (2004)
KEGG	Kyoto encyclopedia of genes and genomes	A collection of manually drawn pathway maps	Kanehisa et al. (2017)
MetaCyc	MetaCyc metabolic pathway database	A curated database of experimentally elucidated pathways	Caspi et al. (2016)
Reactome	NA	A curated, peer-reviewed knowledgebase of biological pathways, including metabolic pathways. It is mainly focused on human pathways	Fabregat et al. (2016)
WikiPathways	NA	A database of biological pathways maintained by and for the scientific community	Kelder et al. (2012)