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. 2017 Dec 14;103(3):497–505. doi: 10.3324/haematol.2017.176164

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Figure 3. — In vivo relationship between BCR signaling and internalization in CLL cells. BCR expression and uptake index were investigated firstly in subsets of peripheral blood (PB) cells (CXCR4^brightCD5^dim and CXCR4^dimCD5^bright expressing CLL cells (A-B), and secondly in CD19⁺CD5⁺ cells from the matched lymph node (LN) and PB samples from seven unmutated CLL patients (C-D). Thirdly, sIgM expression was measured in CD19⁺CD5⁺ PB cells from CLL patients before, one month and at least 12 months after commencing BTKi treatment (ibrutinib, n=6 or acalabrutinib, n=1; presented as a percentage change in surface (s)IgM expression (E-F). Uptake index (G) and the capacity to induce pERK activation following BCR stimulation (H: pERK levels normalized to PMA/positive control) was also examined and compared in CLL B cells, pre- and during treatment. Statistical analysis was performed via Wilcoxon matched pairs test. MFI: mean fluorescent intensity; MESF: molecules of equivalent soluble fluorochrome.