Fig. 7.

Deguelin inhibits tumor growth in xenograft mouse models. (a, b and c) Deguelin significantly inhibited tumor growth in KYSE150 (left) and Eca109 (right) xenograft mouse models. At the treatment endpoint, mice were sacrificed and tumors were removed, weighed and photographed (a). The tumor volume of mice from the vehicle- and the deguelin-treated group was measured (b). The tumor weight from vehicle- and deguelin-treated group was measured (c). Statistical significance was as follows: * p < 0.05, ** p < 0.01, *** p < 0.001 vs. vehicle-treated group. (d) Immunohistochemical staining examination of Ki67 and p-H3-Ser10 in the KYSE150 tumor sections from the mice of the vehicle- or deguelin-treated group. All panels are of the same magnification (* p < 0.05, ** p < 0.01 vs. vehicle-treated group). Scale bar, 100 μm.