Correction to: AGE (2016) 38:513–523
10.1007/s11357-016-9939-5
The original version of this article unfortunately contained a mistake.
The authors regret to inform the readers of a mistake in Table 4 regarding non-effect allele frequencies, which were presented as effect allele frequencies. The correct EAFs should be the originally presented numbers deducted from 1. For example, the EAF for rs4246511 is 0.39 in the originally published version, and the correct value is 0.61(=1–0.39). The correct table is given in this article.
Table 4.
Evaluation of GWAS-identified single nucleotide polymorphisms for age at natural menopause in East Asian women
Locus | SNP | Chr | Base positiona | Nearby gene | Allelesb | EAF | SGWAS (n = 3556) | Stage II (n = 3197) | Combined (n = 6753) | Dir | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta (SE) | P | Beta (SE) | P | Beta (SE) | P_METAL | P_het | ||||||||
1 | rs4246511 | 1 | 39,380,385 | RHBDL2 | T/C | 0.61 | 0.247 (0.089) | 0.006 | 0.303 (0.115) | 0.008 | 0.268 (0.071) | 1.4 × 10−4 | 0.699 | + |
2 | rs1635501 | 1 | 242,040,775 | EXO1 | T/C | 0.77 | −0.025 (0.1) | 0.807 | −0.051 (0.128) | 0.689 | −0.035 (0.079) | 0.661 | 0.869 | – |
3 | rs2303369 | 2 | 27,715,416 | FNDC4 | T/C | 0.13 | 0.065 (0.123) | 0.597 | 0.117 (0.162) | 0.471 | 0.084 (0.098) | 0.391 | 0.801 | – |
4 | rs10183486 | 2 | 171,990,971 | TLK1 | T/C | 0.07 | −0.029 (0.157) | 0.855 | −0.557 (0.222) | 0.012 | −0.204 (0.128) | 0.111 | 0.052 | + |
5 | rs7606918 | 2 | 172,895,449 | MAP1D | A/G | 0.87 | −0.097 (0.127) | 0.443 | 0.308 (0.172) | 0.074 | 0.045 (0.102) | 0.657 | 0.058 | + |
6 | rs4693089 | 4 | 84,373,622 | HEL308 | A/G | 0.33 | −0.107 (0.089) | 0.230 | −0.218 (0.115) | 0.058 | −0.149 (0.071) | 0.035 | 0.447 | + |
7 | rs890835 | 5 | 175,956,271 | RNF44 | A/C | 0.24 | −0.111 (0.099) | 0.259 | −0.063 (0.126) | 0.615 | −0.093 (0.078) | 0.231 | 0.764 | – |
8 | rs365132 | 5 | 176,378,574 | UIMC1 | T/G | 0.52 | 0.229 (0.086) | 0.008 | 0.125 (0.108) | 0.245 | 0.189 (0.067) | 0.005 | 0.450 | + |
9 | rs2153157 | 6 | 10,897,488 | SYCP2L | A/G | 0.68 | 0.165 (0.089) | 0.065 | −0.068 (0.115) | 0.551 | 0.077 (0.071) | 0.276 | 0.109 | + |
10 | rs1046089 | 6 | 31,602,967 | BAT2 | A/G | 0.40 | −0.04 (0.086) | 0.640 | −0.101 (0.166) | 0.543 | −0.053 (0.076) | 0.487 | 0.745 | + |
11 | rs2517388 | 8 | 37,977,732 | ASH2L | T/G | 0.35 | 0.014 (0.091) | 0.876 | −0.165 (0.115) | 0.150 | −0.055 (0.071) | 0.443 | 0.220 | + |
12 | rs12294104 | 11 | 30,382,899 | Intergene | T/C | 0.10 | 0.052 (0.158) | 0.742 | −0.202 (0.257) | 0.431 | −0.018 (0.134) | 0.896 | 0.399 | + |
13 | rs2277339 | 12 | 57,146,069 | PRIM1 | T/G | 0.77 | 0.181 (0.116) | 0.118 | 0.290 (0.167) | 0.082 | 0.216 (0.095) | 0.023 | 0.592 | + |
14 | rs3736830 | 13 | 50,306,221 | KPNA3 | C/G | 0.37 | −0.032 (0.088) | 0.718 | 0.050 (0.113) | 0.657 | −0.001 (0.070) | 0.991 | 0.568 | + |
15 | rs4886238 | 13 | 61,113,739 | TDRD3 | A/G | 0.04 | −0.086 (0.23) | 0.708 | −0.041 (0.324) | 0.899 | −0.071 (0.188) | 0.705 | 0.909 | – |
16 | rs7333181 | 13 | 112,221,297 | Intergene | A/G | 0.04 | −0.147 (0.266) | 0.580 | 0.194 (0.349) | 0.580 | −0.022 (0.212) | 0.917 | 0.438 | + |
17 | rs2307449 | 15 | 89,863,928 | POLG | T/G | 0.64 | 0.210 (0.087) | 0.015 | 0.006 (0.113) | 0.955 | 0.134 (0.069) | 0.050 | 0.153 | + |
18 | rs10852344 | 16 | 12,016,919 | Intergene | T/C | 0.15 | −0.065 (0.122) | 0.598 | 0.027 (0.162) | 0.867 | −0.031 (0.098) | 0.749 | 0.651 | + |
191 | rs11668344 | 19 | 55,833,664 | TMEM150B | A/G | 0.91 | 0.659 (0.145) | 5.6 × 10−6 | 0.247 (0.218) | 0.257 | 0.533 (0.121) | 1.0 × 10−5 | 0.115 | + |
192 | rs12461110 | 19 | 56,320,663 | NLRP11 | A/G | 0.29 | −0.246 (0.092) | 0.008 | 0.157 (0.136) | 0.248 | −0.119 (0.076) | 0.117 | 0.014 | + |
20 | rs16991615 | 20 | 5,948,227 | MCM8 | A/G | 0.01 | −2.783 (1.745) | 0.111 | −0.655 (1.425) | 0.646 | −1.506 (1.103) | 0.172 | 0.345 | – |
SNP single nucleotide polymorphism, Chr chromosome, EAF Effective allele frequency, SE standard error, P_METAL P value from meta-analysis using METAL, P_het P value from between-study heterogeneity test, Dir allelic association direction compared to that from previous GWAS (“+” denotes same and “-” denotes opposite).
aChromosome position based on NCBI human genome build 37 from the 1000 Genomes Project
bShown as effect allele/other allele
Footnotes
The online version of the original article can be found at 10.1007/s11357-016-9939-5