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The 7SK/HEXIM/P-TEFb snRNP controls transcription of both protein-coding and RNAPII-specific spliceosomal snRNA genes. In response to transcriptional stress, P-TEFb and 7SK core snRNP are released from the 7SK/HEXIM/P-TEFb snRNP. While P-TEFb stimulates transcription of protein-coding genes through releasing promoter-proximal paused RNAPII, a fraction of the free 7SK core snRNP associates with the Little Elongation Complex (LEC) to facilitate snRNA genes transcription.
