Figure 1. Potentiation of Hsp90 inhibitor-induced cytotoxicity by celecoxib (CCB) in MDR cells.

MCF7-MDR (A and B), CEM/VLB₁₀₀ (C and D) or HeyA8-MDR cells (E and F) were treated with increasing doses of 17-AAG or AUY922 in the presence or absence of CCB (5 and 10 μM). Percentage of cell survival was determined after 96 h of incubation using the MTT assay. Results are the means ± SEs of three experiments.^* p < 0.05, ^**p < 0.01 and ^***p < 0.001.