Table 1.
Effect of administration of sHDL and T1317 on lipid metabolism and hepatic lipogenesis at different dosage in C57BL/J mice. C57BL/J mice were randomly divided into indicated groups and received once IP injection. Twenty-four hours after injection, the mice were sacrificed.
| Group | Total cholesterol (mg/dL) | HDL cholesterol (mg/dL) | Triglycerides |
|---|---|---|---|
| PBS | 64.0 ± 2.8 | 36.3 ± 1.3 | 79.0 ± 4.3 |
| DMSO | 76.9 ± 10.7 | 45.0 ± 9.2 | 76.3 ± 8.3 |
| T1317 0.5 mg/kg | 110.3 ± 7.2⁎⁎ | 46.3 ± 0.8 | 94.3 ± 12.5⁎ |
| T1317 1.5 mg/kg | 109.3 ± 8.1⁎⁎ | 46.3 ± 5.2 | 101.7 ± 9.6⁎⁎ |
| T1317 3.0 mg/kg | 137 ± 10.4⁎⁎ | 55.7 ± 8.9 | 97.0 ± 4.7⁎⁎ |
| sHDL | 90.0 ± 2.7⁎⁎ | 50.7 ± 4.8 | 72.7 ± 3.3 |
| sHDK-T1317 0.5 mg/kg | 79.7 ± 1.9⁎ | 44.0 ± 3.6 | 75.7 ± 3.9 |
| sHDK-T1317 1.5 mg/kg | 89.7 ± 2.2⁎ | 41.7 ± 1.7 | 72.3 ± 8.4 |
| sHDK-T1317 3.0 mg/kg | 89.0 ± 2.2⁎ | 48.3 ± 4.2 | 72.3 ± 2.5 |
The total cholesterol, HDL-C and triglyceride levels were measured. Data are mean ± S.E.M.; n = 5 per group; ⁎P < 0.05, ⁎⁎P < 0.01 compared to control.