Table 5.
Relative change in breast volume and composition at B4 associated with average pubertal AgeAccel in blood correcting for cellular heterogeneity.
| Percent Change in Geometric Mean (95% CI) |
|||
|---|---|---|---|
| Model 1a | Model 2b | Model 3c | |
| Total Breast Volume | |||
| Continuous (per 5 years) | 0.96 (0.90, 1.03) | 0.95 (0.89, 1.02) | 0.95 (0.89, 1.02) |
| Categorical {ref: (−10, −2]} | 1.00 | 1.00 | 1.00 |
| (−2, 2] | 1.04 (0.93, 1.16) | 1.02 (0.91, 1.15) | 1.02 (0.91, 1.15) |
| (2, 10] | 0.96 (0.84, 1.09) | 0.94 (0.82, 1.09) | 0.94 (0.82, 1.09) |
| Fibroglandular Volume | |||
| Continuous (per 5 years) | 0.99 (0.91, 1.09) | 0.99 (0.90, 1.09) | 0.99 (0.90, 1.09) |
| Categorical {ref: (−10, −2]} | 1.00 | 1.00 | 1.00 |
| (−2, 2] | 1.08 (0.94, 1.24) | 1.06 (0.94, 1.20) | 1.06 (0.94, 1.20) |
| (2, 10] | 1.04 (0.88, 1.23) | 1.04 (0.88, 1.22) | 1.03 (0.87, 1.22) |
| Percent Fibroglandular Volume | |||
| Continuous (per 5 years) | 1.03 (0.98, 1.09) | 1.04 (0.98, 1.10) | 1.04 (0.98, 1.10) |
| Categorical {ref: (−10,−2]} | 1.00 | 1.00 | 1.00 |
| (−2, 2] | 1.04 (0.95, 1.13) | 1.04 (0.95, 1.13) | 1.04 (0.95, 1.13) |
| (2, 10] | 1.08 (0.98, 1.20) | 1.09 (0.99, 1.21) | 1.09 (0.99, 1.20) |
a
Adjusting for fat percentage at breast density measurement and cell-type distribution.
b
Adjusting for variables in Model 1 and birth weight, maternal pre-pregnancy BMI, maternal height, and maternal education.
c
Adjusting for variables in Model 2 and child height Z-score at B2.
*P<0.05, **P<0.01, ***P<0.001.