Table 3.
Exploratory pharmacokinetic parameters.
| Parameter | Unit | 1 mg i.n. | 2 mg i.n. | 4 mg i.n. | 0.4 mg i.m. | 0.4 mg i.v. |
|---|---|---|---|---|---|---|
| AUCp | ||||||
| Geometric mean (CV%) | Hour × ng/ml | 0.05 (112.2) | 0.11 (105.1) | 0.27 (98.6) | 0.11 (67.9) | 0.44 (56.2) |
| Arithmetic mean (SD) | Hour × ng/ml | 0.07 (0.1) | 0.15 (0.1) | 0.36 (0.3) | 0.13 (0.1) | 0.50 (0.2) |
| Range (min, max) | Hour × ng/ml | 0.00, 0.21 | 0.01, 0.56 | 0.04, 1.52 | 0.03, 0.28 | 0.07, 1.12 |
| T50%a | Minute | 10 (5) | 9 (4) | 9 (5) | 4 (1) | 1 (1) |
| T50%ref a | Minute | 10 (8) | 6 (4) | 4 (2) | (4 (1)) | 1 (2) |
a
Arithmetic mean (standard deviation).
AUCp = partial area under the curve with cut‐off at Tmax of reference; T50% = time to 50% of Cmax; T50%ref = time to C50% of 0.4 mg i.m. (primary reference); i.n. = intranasal; i.m. = intramuscular; i.v. = intravenous; SD = standard deviation; CV% = coefficient of variation.