Table 4.
Annualized rates of change in FDG metabolism across regions of interest
| Region of interest | Hem | Control | agPPA | PPAOS | agPPA ∼ Control | PPAOS ∼ Control | agPPA ∼ PPAOS |
|---|---|---|---|---|---|---|---|
| AUROC (P) | AUROC (P) | AUROC (P) | |||||
| Broca’s area | L | −0.006 (0.041) | −0.081 (0.028) | −0.02 (0.029) | 0.934 (<0.001) | 0.631 (0.222) | 0.945 (<0.001) |
| R | −0.004 (0.043) | −0.056 (0.041) | −0.019 (0.036) | 0.812 (0.003) | 0.59 (0.375) | 0.745 (0.089) | |
| Middle frontal | L | −0.011 (0.049) | −0.094 (0.041) | −0.026 (0.035) | 0.908 (<0.001) | 0.615 (0.289) | 0.895 (0.002) |
| R | −0.01 (0.051) | −0.064 (0.056) | −0.023 (0.037) | 0.752 (0.015) | 0.554 (0.509) | 0.705 (0.162) | |
| Superior frontal | L | −0.009 (0.041) | −0.069 (0.044) | −0.018 (0.032) | 0.853 (0.001) | 0.584 (0.382) | 0.836 (0.009) |
| R | −0.005 (0.044) | −0.049 (0.039) | −0.022 (0.033) | 0.757 (0.014) | 0.602 (0.328) | 0.695 (0.185) | |
| Superior medial frontal | L | −0.004 (0.039) | −0.07 (0.038) | −0.017 (0.025) | 0.9 (<0.001) | 0.606 (0.327) | 0.868 (0.005) |
| R | −0.007 (0.036) | −0.05 (0.034) | −0.016 (0.03) | 0.806 (0.004) | 0.565 (0.509) | 0.768 (0.053) | |
| Orbitofrontal cortex | L | −0.002 (0.042) | −0.062 (0.05) | −0.011 (0.032) | 0.815 (0.003) | 0.554 (0.509) | 0.777 (0.045) |
| R | −0.002 (0.041) | −0.03 (0.048) | −0.013 (0.031) | 0.651 (0.154) | 0.565 (0.509) | 0.605 (0.471) | |
| Anterior cingulate | L | 0 (0.039) | −0.05 (0.038) | −0.003 (0.023) | 0.833 (0.002) | 0.555 (0.509) | 0.836 (0.009) |
| R | −0.003 (0.041) | −0.038 (0.055) | −0.008 (0.032) | 0.679 (0.085) | 0.591 (0.375) | 0.636 (0.367) | |
| Middle cingulate | L | −0.002 (0.042) | −0.058 (0.024) | −0.029 (0.025) | 0.89 (<0.001) | 0.699 (0.054) | 0.791 (0.034) |
| R | −0.007 (0.039) | −0.044 (0.048) | −0.026 (0.028) | 0.713 (0.043) | 0.656 (0.158) | 0.6 (0.484) | |
| Insula | L | −0.006 (0.033) | −0.058 (0.027) | −0.013 (0.029) | 0.922 (<0.001) | 0.593 (0.375) | 0.895 (0.002) |
| R | −0.006 (0.031) | −0.034 (0.026) | −0.017 (0.027) | 0.768 (0.01) | 0.594 (0.375) | 0.686 (0.21) | |
| Supplementary motor area | L | −0.006 (0.042) | −0.071 (0.025) | −0.04 (0.023) | 0.912 (<0.001) | 0.788 (0.005) | 0.855 (0.006) |
| R | −0.008 (0.04) | −0.064 (0.041) | −0.038 (0.025) | 0.855 (0.001) | 0.768 (0.007) | 0.682 (0.218) | |
| Rolandic operculum | L | 0 (0.041) | −0.031 (0.047) | −0.026 (0.033) | 0.71 (0.045) | 0.687 (0.075) | 0.545 (0.851) |
| R | −0.001 (0.038) | −0.027 (0.051) | −0.02 (0.033) | 0.628 (0.225) | 0.64 (0.188) | 0.518 (0.955) | |
| Precentral | L | −0.007 (0.04) | −0.053 (0.044) | −0.032 (0.024) | 0.802 (0.004) | 0.742 (0.017) | 0.673 (0.235) |
| R | −0.004 (0.042) | −0.049 (0.047) | −0.032 (0.029) | 0.776 (0.008) | 0.708 (0.046) | 0.609 (0.471) | |
| Postcentral | L | −0.007 (0.038) | −0.037 (0.045) | −0.017 (0.031) | 0.699 (0.055) | 0.586 (0.375) | 0.627 (0.391) |
| R | −0.004 (0.041) | −0.033 (0.049) | −0.021 (0.03) | 0.644 (0.174) | 0.66 (0.154) | 0.527 (0.91) | |
| Paracentral lobule | L | −0.003 (0.04) | −0.017 (0.035) | −0.006 (0.032) | 0.581 (0.481) | 0.524 (0.75) | 0.605 (0.471) |
| R | −0.004 (0.034) | −0.008 (0.044) | −0.013 (0.036) | 0.512 (0.908) | 0.527 (0.743) | 0.541 (0.851) | |
| Lateral temporal | L | −0.002 (0.031) | −0.026 (0.026) | −0.01 (0.021) | 0.745 (0.018) | 0.586 (0.375) | 0.727 (0.111) |
| R | 0 (0.028) | −0.005 (0.03) | −0.012 (0.022) | 0.519 (0.868) | 0.623 (0.267) | 0.627 (0.391) | |
| Medial temporal | L | −0.001 (0.021) | −0.015 (0.017) | −0.004 (0.017) | 0.702 (0.053) | 0.558 (0.509) | 0.668 (0.244) |
| R | −0.003 (0.022) | −0.006 (0.021) | −0.006 (0.019) | 0.532 (0.797) | 0.541 (0.615) | 0.505 (1) | |
| Lateral parietal | L | −0.006 (0.039) | −0.055 (0.029) | −0.02 (0.027) | 0.872 (<0.001) | 0.603 (0.328) | 0.814 (0.018) |
| R | −0.005 (0.039) | −0.032 (0.05) | −0.024 (0.029) | 0.632 (0.213) | 0.644 (0.188) | 0.514 (0.965) | |
| Medial parietal | L | −0.003 (0.046) | −0.056 (0.042) | −0.027 (0.03) | 0.795 (0.005) | 0.65 (0.172) | 0.723 (0.115) |
| R | −0.008 (0.04) | −0.018 (0.058) | −0.027 (0.034) | 0.554 (0.646) | 0.61 (0.317) | 0.541 (0.851) | |
| Occipital lobe | L | −0.012 (0.049) | −0.017 (0.05) | −0.016 (0.039) | 0.521 (0.868) | 0.56 (0.509) | 0.527 (0.91) |
| R | −0.012 (0.048) | −0.006 (0.057) | −0.017 (0.04) | 0.553 (0.646) | 0.559 (0.509) | 0.609 (0.471) | |
| Caudate | L | −0.005 (0.039) | −0.045 (0.029) | −0.015 (0.045) | 0.827 (0.002) | 0.62 (0.269) | 0.727 (0.111) |
| R | −0.007 (0.034) | −0.026 (0.029) | −0.011 (0.046) | 0.692 (0.064) | 0.554 (0.509) | 0.641 (0.356) | |
| Putamen | L | 0.003 (0.045) | −0.037 (0.026) | −0.016 (0.046) | 0.77 (0.01) | 0.64 (0.188) | 0.673 (0.235) |
| R | −0.004 (0.046) | −0.018 (0.054) | −0.012 (0.056) | 0.573 (0.52) | 0.556 (0.509) | 0.5 (1) | |
| Thalamus | L | −0.004 (0.042) | −0.064 (0.024) | −0.037 (0.044) | 0.897 (<0.001) | 0.727 (0.026) | 0.732 (0.111) |
| R | −0.009 (0.041) | −0.052 (0.052) | −0.031 (0.047) | 0.782 (0.007) | 0.68 (0.085) | 0.641 (0.356) |
Results are shown as median (IQR). Reduced metabolism is represented as negative values. All P-values are corrected using the false discovery rate.
Hem = hemisphere; L = left; R = right.