. 2017 Jan 24;140(3):792–803. doi: 10.1093/brain/aww349

Table 2.

Regional ¹¹C-(R)PK11195 BP and ¹¹C-PIB RATIO in subjects with MCI and healthy control subjects, and regional ¹¹C(R)PK11195 BP in amyloid-positive and -negative MCI subjects, at baseline and follow-up

		Frontal		Temporal		Parietal		Occipital		Ant. cing.		Post. cing.		Thalamus		Striatum		Hippo.
Regional ¹¹C-(R)PK11195 BP and ^11C-PIB RATIO in MCI subjects
		PK11195	PIB	PK11195	PIB	PK11195	PIB	PK11195	PIB	PK11195	PIB	PK11195	PIB	PK11195	PIB	PK11195	PIB	PK11195	PIB
Baseline	Mean	0.42	1.53	0.47	1.54	0.43	1.56	0.48	1.47	0.53	1.69	0.57	1.73	0.43	1.26	0.35	1.59	0.48	1.35
	SD	0.1	0.58	0.09	0.54	0.08	0.59	0.09	0.49	0.14	0.62	0.11	0.69	0.07	0.33	0.07	0.47	0.11	0.13
	Increase (B vs. HC)^a	42%	32%	44%	34%	47%	34%	35%	21%	59%	36%	46%	41%	12%	24%	36%	32%	41%	11%
	P-value	0.0079^*	0.0135^*	0.0021^*	0.0060^*	0.0080^*	0.0102^*	0.0071^*	0.0325^*	0.0024^*	0.0069^*	0.0021^*	0.0056^*	0.2013	0.0086^*	0.0066^*	0.0030^*	0.0087^*	0.0031^*
Follow-up	Mean	0.36	1.65	0.39	1.62	0.37	1.64	0.42	1.54	0.36	1.77	0.43	1.85	0.41	1.28	0.33	1.66	0.38	1.38
	SD	0.08	0.64	0.03	0.6	0.04	0.67	0.03	0.52	0.09	0.71	0.1	0.77	0.09	0.33	0.06	0.54	0.08	0.18
	Increase (F vs. HC)^a	20%	43%	18%	41%	26%	41%	18%	27%	7%	43%	10%	51%	7%	26%	26%	38%	11%	17%
	P-value	0.114	0.0054^*	0.0430^*	0.0037^*	0.0500^*	0.0073^*	0.0347^*	0.0144^*	0.3113	0.0056^*	0.2202	0.0030^*	0.3323	0.005^*	0.0221^*	0.0024^*	0.2047	0.0111^*
HC	Mean	0.3	1.16	0.33	1.15	0.29	1.16	0.36	1.21	0.33	1.24	0.39	1.23	0.38	1.02	0.26	1.2	0.34	1.18
HC	SD	0.1	0.07	0.08	0.05	0.12	0.06	0.09	0.06	0.09	0.11	0.1	0.05	0.14	0.09	0.06	0.07	0.09	0.11
B vs. F	Longitudinal change^b	−14%	8%	−16%	5%	−13%	5%	−11%	5%	−29%	5%	−23%	7%	−2%	1%	−6%	4%	−16%	3%
B vs. F	P-value	0.0265	0.0157^*	0.0088^*	0.0101^*	0.0149^*	0.0267	0.0204^*	0.0032^*	0.0079^*	0.0823	0.0062^*	0.0116^*	0.3243	0.3336	0.1445	0.0363	0.0248^*	0.0692

Regional ¹¹C-(R)PK11195 BP in MCI subjects (Aβ+ and Aβ−)
		Aβ+ MCI	Aβ− MCI	Aβ+ MCI	Aβ− MCI	Aβ+ MCI	Aβ− MCI	Aβ+ MCI	Aβ− MCI	Aβ+ MCI	Aβ− MCI	Aβ+ MCI	Aβ− MCI	Aβ+ MCI	Aβ− MCI	Aβ+ MCI	Aβ− MCI	Aβ+ MCI	Aβ− MCI
Baseline	Mean	0.44	0.41	0.52	0.42	0.43	0.44	0.52	0.45	0.55	0.5	0.61	0.53	0.43	0.43	0.35	0.36	0.53	0.43
	SD	0.06	0.07	0.07	0.07	0.08	0.07	0.08	0.08	0.16	0.07	0.1	0.09	0.07	0.06	0.08	0.04	0.11	0.08
	Increase (B vs. HC)^a	47%	36%	60%	29%	46%	49%	44%	25%	67%	51%	57%	35%	13%	12%	35%	37%	55%	27%
	P-value	0.0110^*	0.0601	0.0025^*	0.0021^*	0.0333^*	0.0396^*	0.0161^*	0.0029^*	0.0474^*	0.0364^*	0.0117^*	0.0684	0.2275	0.0105^*	0.0693	0.0313^*	0.0270^*	0.0515
Follow-up	Mean	0.36	0.36	0.39	0.38	0.37	0.36	0.43	0.42	0.32	0.39	0.42	0.44	0.43	0.39	0.3	0.35	0.35	0.43
	SD	0.09	0.06	0.03	0.05	0.05	0.03	0.04	0.03	0.08	0.07	0.08	0.1	0.08	0.09	0.04	0.05	0.06	0.05
	Increase (F vs. HC)^a	19%	21%	19%	17%	27%	24%	18%	17%	−3%	17%	6%	13%	11%	3%	16%	37%	4%	25%
	P-value	0.2019	0.1306	0.0383^*	0.1078	0.0757	0.0725	0.0527	0.0504	0.4218	0.1609	0.3408	0.2313	0.2775	0.4435	0.135	0.0180^*	0.3958	0.0472^*
B vs. F	Longitudinal change^b	−19%	−11%	−25%	−9%	−13%	−16%	−18%	−6%	−42%	−22%	−32%	−16%	−2%	−8%	−14%	−1%	−33%	−2%
B vs. F	P-value	0.0542	0.19	0.0062^*	0.1969	0.0389	0.1043	0.0274	0.2291	0.0418	0.0681	0.0165^*	0.1227	0.4521	0.3406	0.0508	0.4823	0.0117^*	0.3852

Top: ^*Significant P < 0.05 with correction for multiple comparisons. Increase (B vs. HC)^a indicates the group-wise region of interest comparison between baseline MCI patients and healthy controls, while increase (F vs. HC)^a indicates the group-wise region of interest comparison between follow-up MCI patients and healthy controls. ^bLongitudinal change indicates the group-wise region of interest comparison between baseline and follow-up.

Bottom: ^*Significant P < 0.05 with correction for multiple comparisons. Increase (B vs. HC)^a indicates the group-wise region of interest comparison between baseline MCI patients and healthy controls, while increase (F vs. HC)^a indicates the group-wise region of interest comparison between follow-up MCI patients and healthy controls. ^bLongitudinal change indicates the group-wise region of interest comparison between baseline and follow-up.

Aβ+ MCI = amyloid positive MCI; Aβ−MCI = amyloid negative MCI; Ant. cing = anterior cingulate; B vs. F = baseline versus follow-up; Frontal = frontal lobe; HC = healthy controls; Hippo = hippocampus; Occipital = occipital lobe; Parietal = parietal lobe; PIB = ¹¹C-PIB; PK11195 = ¹¹C-(R)PK11195; Post. cing. = posterior cingulate; Temporal = temporal lobe.