Table 2. Levels of IL-17 associated cytokines produced from PBMC contributing to HNC clinicopathologic status.

	IL-17	IL-21	TGF-β	IL-6	IL-1β
Healthy donor	125.2 ± 22.19	31.98 ± 10.11	1873 ± 242.3	2042 ± 427.9	1198 ± 283.5
HNC	279.5 ± 33.72	86.84 ± 7.530	3368 ± 255.9*	659.7 ± 143.9***	525.5 ± 131.2*
Early stage (I + II)	197.3 ± 46.79	108 ± 17.28**	3124 ± 459.3	832.2 ± 268.5*	857.5 ± 307.6
Late stage (III + IV)	327.9 ± 44.58*	74.34 ± 5.63***	3513 ± 305.9**	558 ± 165.9***	319.1 ± 92.56***

^aHealthy donor n = 11, Early stage n = 23 , Advanced stage n = 39.

^bData were presented as means ± SEM (pg/mL).

^cP value reflects t test analysis of cytokine values from HNC patients compared with healthy donors.

^*P < 0.05, ^**P < 0.01, ^***P < 0.001.