Figure 4.

Associations between N-truncated amyloid-β₄₂ accumulation and proteins related to amyloid-β metabolism, or accumulation of tau and apoE across brain areas or disease stages. Amyloid-β_t-42 levels or amyloid-β_pE11-42 levels in GuHCl fraction are plotted against neprilysin (NEP) levels (A) and BACE1 levels (B) in each brain area of Alzheimer’s disease cases. Amyloid-β_t-42 levels or amyloid-β_pE11-42 levels in GuHCl fraction are plotted against tau levels (C) or apoE levels (D) in GuHCl fraction in each brain area of Alzheimer’s disease cases. Values are median with 25 and 75 percentiles. Amyloid-β_t-42 levels or amyloid-β_pE11-42 levels in GuHCl fraction are plotted against tau levels (E) or apoE levels (F) in GuHCl fraction averaged across seven cortical areas of individual pathological ageing or Alzheimer’s disease cases. Correlation coefficient (r) and P-value were acquired by Spearman rank correlation test. PA = pathological ageing. Blue text = neocortical areas; purple text = limbic areas; and orange text = subcortical areas. Aβ = amyloid-β; AM = amygdala; CB = cerebellum; DF = dorsolateral prefrontal cortex; EC = entorhinal cortex; HT = hypothalamus; IP = inferior parietal cortex; IT = inferior temporal cortex; OF = orbitofrontal cortex; PC = posterior cingulate cortex; ST = striatum; TL = thalamus; VC = primary visual cortex.