Skip to main content
. Author manuscript; available in PMC: 2018 Mar 7.
Published in final edited form as: Neuropharmacology. 2017 Nov 6;129:26–35. doi: 10.1016/j.neuropharm.2017.11.007

Fig. 5. Impact of J147 on tactile allodynia in diabetes.

Fig. 5

J147 acutely ameliorated tactile allodynia in both diabetic mice and rats. Acute treatment with J147 (10–50 mg/kg ip) rapidly increased PWT (A), with maximal changes from baseline (p < 0.01–0.001) noted 1hr after treatment (B). The change from baseline PWT following 50 mg/kg J147 given orally did not correspond to changes in rotarod performance. (C). J147 treatment also induced a 2-fold change in baseline PWT of STZ-diabetic rats (D). Data are group mean + SEM of n = 7–10/ group. Statistical analysis by two-way ANOVA with Tukey’s post-hoc test for A and C; one-way ANOVA with Tukey-Kramer post-hoc test for B and D. * = p < 0.05 STZ + Vehicle vs STZ + J147, + = p < 0.01 STZ + Vehicle vs STZ + J147 (10 mg/kg and 50 mg/kg), ++ = p < 0.001 STZ + Vehicle vs STZ + J147 (10 mg/kg and 50 mg/kg), ** = p < 0.01, *** = p < 0.001, **** = p < 0.0001.