Skip to main content
. Author manuscript; available in PMC: 2018 Jul 24.
Published in final edited form as: Nature. 2018 Jan 24;555(7695):269–273. doi: 10.1038/nature25758

Figure 4. The hydrophobic “patch” of the DRD2 binding pocket.

Figure 4

a, Risperidone (yellow) bound to DRD2 (green) orthosteric pocket viewed from extracellular space. b, The W100EL1 side chain forms extensive hydrophobic contacts with residues L942.64 and I184EL2. c, The residues L942.64, W 100EL1 and I184EL2 form a patch (red, with other residues in grey) that narrows DRD2’s binding pocket.