Table 2. Genes involved in DSBs and recombination.

Gene symbol	Common name (homolog)	Functiona	References
spn-B	Rad51/Dmc1	Strand invasion	Ghabrial et al. (1998)
spn-D	Rad51C	Strand invasion	Ghabrial et al. (1998)
okr	Rad54	Strand invasion	Ghabrial et al. (1998)
rec	Mcm8	Crossover promotion	Grell and Generoso (1980); Blanton et al. (2005); Kohl et al. (2012); Hatkevich et al. (2017)
mei-218	MCM family-related	Crossover promotion	Carpenter and Sandler (1974); McKim et al. (1996); Kohl et al. (2012)
mei-217	MCM family-related	Crossover promotion	Liu et al. (2000); Kohl et al. (2012)
mcm5	Mcm5	Crossover promotion	Lake et al. (2007)
blm	Blm	Crossover promotion	McVey et al. (2007); Kohl et al. (2012); Hatkevich et al. (2017)
mre11	Mre11	DSB repair	Kusch (2015)
p53	p53	Stress response	Lu et al. (2010)
DSB formation
mei-W68	Spo11	DSB formation	McKim and Hayashi-Hagihara (1998); Mehrotra and McKim (2006)
mei-P22	TopoVIB family	DSB formation	McKim et al. (1998); Liu et al. (2002); Mehrotra and McKim (2006)
vilya	E3 ligase	DSB formation; crossover maturation	Lake et al. (2015); Lake and Hawley (2016)
trem		DSB formation	Lake et al. (2011)
Resolvase
mei-9	Rad1/XPF/ERCC4		Carpenter and Sandler (1974); Sekelsky et al. (1995)
mus312	Slx4		Green (1981); Yildiz et al. (2002); 2004
ercc1	ERCC1		Yildiz et al. (2002); Radford et al. (2007)
hdm	MEIOB		Joyce et al. (2009)

MCM, mini-chromosome maintenance; DSB, double-strand break.

^aMost likely function based on genetic, biochemical, or cytological data.