Table 4. Genes involved in spindle assembly and segregation.
Gene symbol | Common name (homolog) | Functiona | References |
---|---|---|---|
ncd | Kinesin family member C1 | Bundles microtubules | Hatsumi and Endow (1992a); Matthies et al. (1996) |
asp | Aspm | Microtubule-associated protein | Saunders et al. (1997); Riparbelli et al. (2002) |
Klp54D | Kinesin family member 12 | Spindle symmetry | Radford et al. (2017) |
Klp61F | Kinesin family member 11 | Spindle symmetry | Radford et al. (2017) |
Klp10A | Kinesin-13 | Spindle assembly | Zou et al. (2008); Radford et al. (2012a); Do et al. (2014) |
Eb1 | Mapre family | Microtubule binding | Do et al. (2014) |
aurB | Aurora Kinase B | Chromosomal passenger complex; spindle midzone | Radford et al. (2012b) |
Incenp | Incenp | Chromosomal passenger complex; spindle midzone | Colombie et al. (2008); Radford et al. (2012b) |
sub | MKLP-2/kinesin 6 | Spindle midzone | Giunta et al. (2002); Jang et al. (2005); Radford et al. (2017) |
tum | RacGAP50C | Centralspindlin complex; spindle midzone | Das et al. (2016) |
mei-38 | TPX2 | Promotes kinetochore microtubules | Baker and Carpenter (1972); Wu et al. (2008) |
msps | XMAP215/TOG | Maintains bipolarity | Cullen and Ohkura (2001) |
cks30A | CKs/Suc1 | Spindle assembly | Cullen et al. (2005) |
d-tacc | D-TACC | Maintains bipolarity | Cullen and Ohkura (2001) |
α-Tub67C | Maternally loaded α-tubulin | Microtubule nucleation | Matthies et al. (1999) |
γ-Tub37C | γ-tubulin | Microtubule nucleation | Tavosanis et al. (1997); Hughes et al. (2011) |
Augmin complex | Chromosome alignment and movement | Meireles et al. (2009); Colombie et al. (2013) | |
Grip71 | γTurc complex | Microtubule nucleation | Reschen et al. (2012) |
Sentin/ ssp2 | Kinetochore attachment to microtubules | Gluszek et al. (2015) | |
rod | Kntc1 | Rzz complex; spindle assembly checkpoint | Gluszek et al. (2015) |
Top2 | Topoisomerase 2 | Chromosome orientation | Hughes and Hawley (2014) |
nod | Nonmotile member of kinesin family | Polar ejection force; chromosome alignment | Baker and Carpenter (1972); Zhang and Hawley (1990); Zhang et al. (1990); Theurkauf and Hawley (1992); Hughes et al. (2009) |
Axs | Ano family | Spindle width; achiasmate chromosome segregation | Zitron and Hawley (1989); Kramer and Hawley (2003a) |
mps1/ald | Mps1 | Meiotic spindle assembly checkpoint; chromosome segregation | O’Tousa (1982); Gilliland et al. (2005), (2007) |
cnn | Centrosomin | Central aster of meiosis II spindles | Riparbelli and Callaini (2005) |
Grip75 | γTurc Complex | Meiosis II spindle assembly | Vogt et al. (2006) |
Grip128 | γTurc Complex | Meiosis II spindle assembly | Vogt et al. (2006) |
Mud | NuMa | Meiosis II central aster | Yu et al. (2006) |
sra | RCAN | Meiosis II entry; oocyte activation | Horner et al. (2006); Takeo et al. (2006); (2010) |
canB2 | calcineurin regulatory subunit B | Meiosis II entry; oocyte activation | Takeo et al. (2010) |
mei-S332 | Shugoshin | Protection of centromeric cohesion | Kerrebrock et al. (1992), (1995) |
cort | Cortex | APC; Meiosis II progression; egg activation | Page and Orr-Weaver (1996); Whitfield et al. (2013) |
grau | Grauzone | Meiosis II progression; egg activation; destruction of proteins | Page and Orr-Weaver (1996) |
fzy | Cdc20 (APC) | Meiosis II progression; destruction of proteins | Swan and Schupbach (2007) |
APC, anaphase-promoting complex.
Most likely function based on genetic, biochemical, or cytological data.