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. 2018 Jan 30;9(15):12137–12153. doi: 10.18632/oncotarget.24343

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Copyright: © 2018 Lei et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Western blot for Dicer and β-actin in injured retinas administered with agomir-let-7d or agomir-Nc. (B) HE staining shows the thickness of retinas injured for 7 days after let-7d overexpression. (C) Immunofluorescent staining by Tuj1 on retinal flat mounting displays the survival of RGCs in IR-injured retinas after let-7d overexpression. (D) Analysis of retinal thickness of IR-injured retinas after let-7d overexpression. (E) Analysis of the survival of RGCs in IR-injured retinas by Tuj1 immunostaining on retinal flat mounting after let-7d overexpression. (F) Photopic visual acuity of RIR-injured mice after let-7 overexpression. Data were shown as mean ± SEM (G) Percent time spent in the light chamber by RIR-injured mice after intravitreal injection of let-7d Agomir. n = 8, ^##p < 0.01, ^####p < 0.0001, versus control; ^***p < 0.001, ^****p < 0.0001, versus vehicle; ns: no significance.