Table 1. Comparison of demographics and history of comorbidity between ACOS and non-ACOS cohorts.
| ACOS | |||||
|---|---|---|---|---|---|
| No (N = 20513) | Yes (N = 10260) | ||||
| Variable | n | % | n | % | p-value |
| Sex | 0.99 | ||||
| Female | 8826 | 43.0 | 4414 | 43.0 | |
| Male | 11687 | 57.0 | 5846 | 57.0 | |
| Age, year | 0.99 | ||||
| 40–49 | 2470 | 12.0 | 1235 | 12.0 | |
| 50–64 | 6736 | 32.8 | 3368 | 32.8 | |
| ≥65 | 11307 | 55.1 | 5657 | 55.1 | |
| Mean (SD)# | 65.5 | 11.9 | 65.6 | 11.8 | 0.38 |
| Comorbidity | |||||
| Diabetes | 4019 | 19.6 | 2425 | 23.6 | < .0001 |
| Hypertension | 9659 | 47.1 | 6254 | 61.0 | < .0001 |
| Hyperlipidemia | 5065 | 24.7 | 3271 | 31.9 | < .0001 |
| Coronary artery disease | 5044 | 24.6 | 4065 | 39.6 | < .0001 |
| Alcohol-related illness | 469 | 2.29 | 494 | 4.81 | < .0001 |
| Sleep disorder | 3659 | 17.8 | 3063 | 29.9 | < .0001 |
| Anxiety | 1371 | 6.68 | 1223 | 11.9 | < .0001 |
| Atopic related diseases | 5586 | 27.2 | 4739 | 46.2 | < .0001 |
| Cancer | 756 | 3.69 | 396 | 3.86 | 0.45 |
| Tuberculosis | 466 | 2.27 | 782 | 7.62 | < .0001 |
| Pneumonia | 1005 | 4.90 | 1785 | 17.4 | < 0.001 |
| Medicine | |||||
| Inhaled corticosteroids (ICSs) | 652 | 3.18 | 2722 | 26.5 | < .0001 |
| Oral steroids(OSs) | 8243 | 40.2 | 7941 | 77.4 | < .0001 |
ACOS, asthma–COPD overlap syndrome; Chi-square test; #Student’s t-test.