Fig. 6.

FOXO3a and FOXM1 modulates GOF mutant p53-mediated cell invasion in vitro. a, f Representative images from the Transwell invasion assay of UM-SCC-1 stable cell lines. b, g Quantitation of invasive cells in a and f, respectively. *p < 0.05; **p < 0.01. c, h Representative images of 3D cultures of UM-SCC-1 stable cell lines. Bar, 100 μm. d, i Quantitation of 3D tumor spheroids that were round or had protrusion in c and h, respectively. *<0.05; **p < 0.01. e Western blot analysis of isogenic UM-SCC-1 stable cell lines in the presence or absence of metabolic stress under the confluent high-density culture condition