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. 2018 Mar 12;7:307. [Version 1] doi: 10.12688/f1000research.13179.1

Figure 3. The programmed death-1 receptor pathway.

Figure 3.

Recognition of foreign or tumor antigens normally results in the activation of CD8 T cells, leading to the killing of viruses or bacteria or the lysis of tumor cells. The programmed death-1 (PD-1) receptor is a cell membrane protein present on the surface of CD8 T cells, which, upon interacting with PD-L1 and PD-L2 on the surface of tumor cells, results in the suppression of the cytotoxic immune response, leading to tumor escape.IFN, interferon; IL-2, interleukin-2; MHC, major histocompatibility complex; PD-1, programmed death-1; PD-L1, programmed death ligand-1; TCR, T-cell receptor.