Table 2. Univariate and multivariate analysis of different prognostic variables in patients with ESCC.
| Clinical–pathological features |
Univariable analysis |
Multivariable analysis |
||
|---|---|---|---|---|
| HR (95% CL) | P-value | HR (95% CL) | P-value | |
| Age | 1.094 (0.725–1.650) | 0.670 | ||
| Gender | 1.009 (0.666–1.529) | 0.966 | ||
| Differetiation | 1.375 (0.991–1.910) | 0.057 | ||
| Tumor invasion | 2.562 (1.923–3.413) | <0.001 | 1.166 (0.674–2.018) | 0.582 |
| Lymph nodes metastasis | 5.063 (3.316–7.729) | <0.001 | 2.434 (1.545–3.835) | <0.001 |
| TNM stage | 8.017 (4.244–15.143) | <0.001 | 3.736 (1.067–13.078) | 0.039 |
| DHRS2 downregulation | 2.283 (1.504–3.466) | <0.001 | 1.307 (0.851–2.008) | 0.221 |
Abbreviations: CI, confidence interval; DHRS2, short-chain dehydrogenase/reductase family, member 2; ESCC, esophageal squamous cell carcinoma; HR, hazard ratio; TNM staging system (T, tumor; N, lymph node; M, metastasis). Bold values indicate statistically significant.