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. 2017 Nov 8;43(5):1119–1127. doi: 10.1038/npp.2017.229

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Copyright © 2018 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Individuals with major depressive disorder (MDD) exhibited lower intrinsic functional connectivity in the medial prefrontal cortex (mPFC). Single group ICD maps for (a) HC participants and (b) individuals with MDD show greatest connectivity in midline ‘hub’ regions with visually reduced ICD connectivity in the vmPFC for the MDD patients. (c) For MDD compared to HC, the vmPFC exhibited significantly (p<0.05 corrected) reduced ICD connectivity. (d) For individuals with MDD, ICD connectivity in the ventral anterior cingulate cortex (vACC) was inversely correlated with Hamilton Depression Rating Scale (1st 17). Images shown at p<0.05, corrected for multiple comparisons.