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. 2018 Feb 12;8(6):1740–1751. doi: 10.7150/thno.22010

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Prognostic significance of TERT promoter mutations and amplification in HCC. (A) Kaplan-Meier survival analysis with respect to TERT promoter mutation status. (B) Amplification of 5q15.33 was associated with shortened overall survival in HCC patients. (C) Significant positive correlation between TERT Gistic score and mRNA expression levels in TERT-amplified samples. (D) HCC patients with TERT amplifications exhibited poorer overall survival. (E) Multivariate Cox regression analysis of HCCs with or without TERT amplification in relation to age, gender, race, HBV status and TNM staging.