Table 2.
Discrimination and calibration of the non-laboratory INTERHEART Risk Score for incident cardiovascular disease
| Outcome*/N (%) | Discrimination | Calibration | ||
| C-stat (95% CI) | Intercept (95% CI) |
Slope (95% CI) |
||
| Original NL-IHRS | ||||
| Overall PURE population | 2284/100 475 (2.27) | 0.69 (0.68 to 0.70) | −3.85 (−3.90 to 3.81) | 0.77 (0.73 to 0.82) |
| Geographic region | ||||
| South Asia | 525/12 130 (4.33) | 0.67 (0.64 to 0.69) | −3.03 (−3.12 to 2.94) | 0.75 (0.65 to 0.86) |
| China | 568/38 431 (1.48) | 0.69 (0.67 to 0.71) | −4.06 (−4.14 to 3.97) | 0.81 (0.71 to 0.91) |
| Southeast Asia | 137/6892 (1.99) | 0.73 (0.69 to 0.77) | −4.17 (−4.38 to 3.97) | 0.92 (0.72 to 1.12) |
| Africa | 50/1291 (3.87) | 0.64 (0.56 to 0.72) | −3.27 (−3.57 to 2.97) | 0.75 (0.36 to 1.15) |
| North America/Europe | 523/16 148 (3.24) | 0.69 (0.67 to 0.72) | −3.70 (−3.80 to 3.59) | 0.77 (0.68 to 0.87) |
| Middle East | 129/5626 (2.29) | 0.74 (0.70 to 0.78) | −4.00 (−4.21 to 3.79) | 1.06 (0.86 to 1.26) |
| South America | 352/19 957 (1.76) | 0.72 (0.69 to 0.75) | −4.43 (−4.57 to 4.29) | 0.87 (0.77 to 0.98) |
| Country income status | ||||
| HIC | 328/12 160 (2.70) | 0.68 (0.65 to 0.71) | −3.85 (−3.98 to 3.72) | 0.72 (0.60 to 0.83) |
| MIC | 1400/75 597 (1.85) | 0.71 (0.70 to 0.73) | −4.08 (−4.14 to 4.02) | 0.85 (0.80 to 0.91) |
| LIC | 556/12 718 (4.37) | 0.67 (0.64 to 0.69) | −3.01 (−3.10 to 2.93) | 0.76 (0.65 to 0.86) |
| Recalibrated NL-IHRS | ||||
| Overall PURE population | 2284/100 475 (2.27) | 0.72 (0.71 to 0.73) | −0.003 (−0.18 to 0.17) | 1 (0.95 to 1.05) |
| Geographic region | ||||
| South Asia | 525/12 130 (4.33) | 0.67 (0.64 to 0.69) | 0 (−0.42 to 0.42) | 1 (0.86 to 1.14) |
| China | 568/38 431 (1.48) | 0.69 (0.67 to 0.71) | 0 (−0.49 to 0.49) | 1 (0.88 to 1.12) |
| Southeast Asia | 137/6892 (1.99) | 0.73 (0.69 to 0.77) | 0 (−0.80 to 0.80) | 1 (0.78 to 1.22) |
| Africa | 50/1291 (3.87) | 0.64 (0.56 to 0.72) | 0 (−1.62, 1.62) | 1 (0.48 to 1.52) |
| North America/Europe | 523/16 148 (3.24) | 0.69 (0.67 to 0.72) | 0 (−0.40 to 0.40) | 1 (0.88 to 1.12) |
| Middle East | 129/5626 (2.29) | 0.74 (0.70 to 0.78) | 0 (−0.65 to 0.65) | 1 (0.81 to 1.19) |
| South America | 352/19 957 (1.76) | 0.72 (0.69 to 0.75) | 0 (−0.48 to 0.48) | 1 (0.87 to 1.13) |
| Country income status | ||||
| HIC | 328/12 160 (2.70) | 0.69 (0.66 to 0.71) | −0.48 (−0.98 to 0.01) | 0.91 (0.76 to 1.06) |
| MIC | 1400/75 597 (1.85) | 0.72 (0.71 to 0.74) | 0.22 (−0.03 to 0.46) | 1.05 (0.98 to 1.11) |
| LIC | 556/12 718 (4.37) | 0.66 (0.64 to 0.69) | −0.01 (−0.43 to 0.40) | 0.99 (0.85 to 1.13) |
*Cardiovascular disease defined as cardiac death, stroke, myocardial infarction, heart failure and revascularisation.
C-stat, concordance statistic; HIC, high-income countries; LIC, low-income country; MIC, middle-income country; NL-IHRS, non-laboratory INTERHEART risk score; PURE, Prospective Urban Rural Epidemiology.